Increased EEG gamma power under exposure to drug-related cues: a translational index for cue-elicited craving in METH-dependent individuals

被引：2

作者：

Li, Dong-xu ^{[1
]}

Zhou, Xiang-yi ^{[1
]}

Lin, Qian-qian ^{[2
]}

Wu, Yue ^{[3
]}

Hu, Cheng ^{[4
]}

Shen, Zhi-hua ^{[2
]}

Wang, Yong-guang ^{[1
,2
,3
,5
]}

机构：

[1] Anhui Med Univ, Sch Mental Hlth & Psychol Sci, Hefei, Anhui, Peoples R China

[2] Hangzhou Seventh Peoples Hosp, Affiliated Mental Hlth Ctr, 305 Tianmushan Rd, Hangzhou, Zhejiang, Peoples R China

[3] Fifth Hosp Ruian, Ruian, Zhejiang, Peoples R China

[4] Shiliping Compulsory Rehabil Ctr, Hangzhou, Zhejiang, Peoples R China

[5] Zhejiang Prov Inst Drug Abuse Res, Hangzhou, Zhejiang, Peoples R China

来源：

BMC PSYCHIATRY | 2023年 / 23卷 / 01期

关键词：

Methamphetamine; Craving; Virtual reality; Counterconditioning; Gamma oscillations; EXECUTIVE CONTROL; BAND ACTIVITY; OSCILLATIONS; ATTENTION; SMOKING; LIKING; BETA; MODULATION; REACTIVITY; RESPONSES;

D O I：

10.1186/s12888-023-04892-9

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

BackgroundThis study explored the feasibility of using EEG gamma-band (30-49 Hz) power as an index of cue-elicited craving in METH-dependent individuals.MethodsTwenty-nine participants dependent on methamphetamine (METH) and 30 healthy participants were instructed to experience a METH-related virtual reality (VR) social environment.ResultsIndividuals with METH dependence showed significantly stronger self-reported craving and higher gamma power in a VR environment than healthy individuals. In the METH group, the VR environment elicited a significant increase in gamma power compared with the resting state. The METH group then received a VR counterconditioning procedure (VRCP), which was deemed useful in suppressing cue-induced reactivity. After VRCP, participants showed significantly lower self-reported craving scores and gamma power when exposed to drug-related cues than the first time.ConclusionsThese findings suggest that the EEG gamma-band power may be a marker of cue-induced reactivity in patients with METH dependence.

引用

页数：9