The Biosafety Research Road Map: The Search for Evidence to Support Practices in Human and Veterinary Laboratories

被引：9

作者：

Blacksell, Stuart D. ^{[1
,2
,16
]}

Dhawan, Sandhya ^{[1
]}

Kusumoto, Marina ^{[1
]}

Le, Kim Khanh ^{[1
]}

Summermatter, Kathrin ^{[3
]}

O'Keefe, Joseph ^{[4
]}

Kozlovac, Joseph ^{[5
]}

Almuhairi, Salama Suhail ^{[6
,15
]}

Sendow, Indrawati ^{[7
]}

Scheel, Christina M. ^{[8
]}

Ahumibe, Anthony ^{[9
]}

Masuku, Zibusiso M. ^{[10
]}

Bennett, Allan M. ^{[11
]}

Kojima, Kazunobu ^{[12
]}

Harper, David R. ^{[13
]}

Hamilton, Keith ^{[14
]}

机构：

[1] Mahidol Univ, Fac Trop Med, Mahidol Oxford Trop Res Med Unit, Bangkok, Thailand

[2] Univ Oxford, Ctr Trop Med & Global Hlth, Nuffield Dept Med, Nuffield Dept Med Res Bldg, Oxford, England

[3] Univ Bern, Inst Infect Dis, Bern, Switzerland

[4] Minist Primary Ind, Wellington, New Zealand

[5] USDA ARS, Beltsville, MD USA

[6] Abu Dhabi Agr & Food Safety Author, Abu Dhabi, U Arab Emirates

[7] Natl Res & Innovat Agcy, Res Ctr Vet Sci, Jakarta, Indonesia

[8] CDCP, WHO Collaborating Ctr Biosafety & Biosecur, Ctr Global Hlth, Lab Sci, Atlanta, GA USA

[9] Nigeria Ctr Dis Control & Prevent, Abuja, Nigeria

[10] Natl Inst Communicable Dis, Natl Hlth Lab Serv, Johannesburg, South Africa

[11] UK Hlth Secur Agcy, Porton Down, Salisbury, England

[12] World Hlth Org WHO, Dept Epidem & Pandem Preparedness & Prevent, Geneva, Switzerland

[13] Royal Inst Int Affairs, London, England

[14] World Org Anim Hlth OIE, Paris, France

[15] Natl Emergency Crisis & Disaster Management Author, Abu Dhabi, U Arab Emirates

[16] Mahidol Univ, Fac Trop Med, Mahidol Oxford Trop Res Med Unit, 420-6 Rajvithi Rd, Bangkok 10400, Thailand

来源：

APPLIED BIOSAFETY | 2023年 / 28卷 / 02期

基金：

英国惠康基金;

关键词：

miscellaneous pathogens; respiratory pathogens; bioterrorism; zoonotic pathogens; viral hemorrhagic fevers; biosafety gap;

D O I：

10.1089/apb.2022.0040

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Introduction: Lack of evidence-based information regarding potential biological risks can result in inappropriate or excessive biosafety and biosecurity risk-reduction strategies. This can cause unnecessary damage and loss to the physical facilities, physical and psychological well-being of laboratory staff, and community trust. A technical working group from the World Organization for Animal Health (WOAH, formerly OIE), World Health Organization (WHO), and Chatham House collaborated on the Biosafety Research Roadmap (BRM) project. The goal of the BRM is the sustainable implementation of evidence-based biorisk management of laboratory activities, particularly in low-resource settings, and the identification of gaps in the current biosafety and biosecurity knowledge base.Methods: A literature search was conducted for the basis of laboratory design and practices for four selected high-priority subgroups of pathogenic agents. Potential gaps in biosafety were focused on five main sections, including the route of inoculation/modes of transmission, infectious dose, laboratory-acquired infections, containment releases, and disinfection and decontamination strategies. Categories representing miscellaneous, respiratory, bioterrorism/zoonotic, and viral hemorrhagic fever pathogens were created within each group were selected for review.Results: Information sheets on the pathogens were developed. Critical gaps in the evidence base for safe sustainable biorisk management were identified.Conclusion: The gap analysis identified areas of applied biosafety research required to support the safety, and the sustainability, of global research programs. Improving the data available for biorisk management decisions for research with high-priority pathogens will contribute significantly to the improvement and development of appropriate and necessary biosafety, biocontainment and biosecurity strategies for each agent.

引用

页码：64 / 71

页数：8

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