Medication adherence and cognitive performance in schizophrenia-spectrum and bipolar disorder: results from the PsyCourse Study

被引：8

作者：

Senner, Fanny ^{[1
,2
]}

Hiendl, Lena ^{[3
]}

Bengesser, Susanne ^{[3
]}

Adorjan, Kristina ^{[1
,2
]}

Anghelescu., Ion-George ^{[4
]}

Baune., Bernhardt T. ^{[5
,6
,8
]}

Budde, Monika. ^{[2
]}

Dannlowski, Udo ^{[7
]}

Dietrich, Detlef E. ^{[9
,10
]}

Falkai, Peter ^{[1
]}

Fallgatter, Andreas J. ^{[11
]}

Hasan, Alkomiet ^{[12
]}

Heilbronner, Maria ^{[2
]}

Jaeger, Markus ^{[13
]}

Juckel, Georg ^{[14
]}

Kalman, Janos L. ^{[1
,2
]}

Konrad, Carsten ^{[15
]}

Kohshour, Mojtaba Oraki ^{[2
,16
]}

Papiol, Sergi ^{[1
,2
]}

Reich-Erkelenz, Daniela ^{[2
]}

Reimer, Jens ^{[17
,18
]}

Schaupp, Sabrina K. ^{[2
]}

Schmauss, Max ^{[12
]}

Senner, Simon ^{[19
]}

Spitzer, Carsten ^{[20
]}

Vogl, Thomas ^{[2
]}

Zimmermann, Joerg ^{[21
]}

Heilbronner, Urs ^{[2
]}

Schulte, Eva C. ^{[1
,2
,22
,23
]}

Schulze, Thomas G. ^{[2
,24
]}

Reininghaus, Eva Z. ^{[3
]}

Kirchner, Sophie-Kathrin ^{[1
,12
]}

Dalkner, Nina ^{[3
]}

机构：

[1] Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Psychiat & Psychotherapy, D-80336 Munich, Germany

[2] Ludwig Maximilians Univ Munchen, Univ Hosp, Inst Psychiat Phen & Genom, D-80336 Munich, Germany

[3] Med Univ Graz, Dept Psychiat & Psychotherapeut Med, Res Unit Neurobiol & Anthropometr Bipolar Affect, A-8036 Graz, Austria

[4] Mental Hlth Inst Berlin, Dept Psychiat & Psychotherapy, D-14050 Berlin, Germany

[5] Univ Munster, Dept Psychiat, D-48149 Munster, Germany

[6] Univ Melbourne, Melbourne Med Sch, Dept Psychiat, Melbourne, Vic, Australia

[7] Univ Munster, Inst Translat Psychiat, D-48149 Munster, Germany

[8] AMEOS Clin Ctr Hildesheim, D-31135 Hildesheim, Germany

[9] Ctr Syst Neurosci ZSN, D-30559 Hannover, Germany

[10] Med Sch Hannover, Dept Psychiat, D-30625 Hannover, Germany

[11] Univ Tubingen, Tubingen Ctr Mental Hlth, Dept Psychiat & Psychotherapy, D-72076 Tubingen, Germany

[12] Univ Augsburg, Dept Psychiat Psychotherapy & Psychosomat, Fac Med, Bezirkskrankenhaus Augsburg, D-86156 Augsburg, Germany

[13] Ulm Univ, Bezirkskrankenhaus Gunzburg, Dept Psychiat 2, D-89312 Gunzburg, Germany

[14] Ruhr Univ Bochum, LWL Univ Hosp, Dept Psychiat, D-44791 Bochum, Germany

[15] Agaples Diakonieklinikum, Dept Psychiat & Psychotherapy, D-27356 Rotenburg, Germany

[16] Ahvaz Jundishapur Univ Med Sci, Dept Immunol, Fac Med, Ahvaz, Iran

[17] Univ Med Ctr Hamburg Eppendorf, Dept Psychiat & Psychotherapy, D-20246 Hamburg, Germany

[18] Hlth North Hosp Grp, Dept Psychiat, D-28102 Bremen, Germany

[19] Acad Hosp Univ Konstanz, Ctr Psychiat Reichenau, D-78479 Constance, Germany

[20] Univ Med Ctr Rostock, Dept Psychosomat Med & Psychotherapy, D-18147 Rostock, Germany

[21] Psychiatrieverbund Oldenburger Land gGmbH, Karl Jaspers Klin, D-26160 Bad Zwischenahn, Germany

[22] Univ Bonn, Univ Hosp Bonn, Fac Med, Dept Psychiat & Psychotherapy, D-53105 Bonn, Germany

[23] Univ Bonn, Univ Hosp Bonn, Fac Med, Inst Human Genet, D-53127 Bonn, Germany

[24] SUNY Upstate Med Univ, Dept Psychiat & Behavorial Sci, Syracuse, NY 13210 USA

来源：

TRANSLATIONAL PSYCHIATRY | 2023年 / 13卷 / 01期

基金：

欧盟地平线“2020”;

关键词：

ANTIPSYCHOTIC MEDICATION; RATING-SCALE; IMPAIRMENT; THERAPY; METAANALYSES; REMEDIATION; DEFICITS; LITHIUM; MEMORY;

D O I：

10.1038/s41398-023-02373-x

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Existing guidelines recommend psychopharmacological treatment for the management of schizophrenia and bipolar disorder as part of holistic treatment concepts. About half of the patients do not take their medication regularly, although treatment adherence can prevent exacerbations and re-hospitalizations. To date, the relationship between medication adherence and cognitive performance is understudied. Therefore, this study investigated the relationship between medication adherence and cognitive performance by analyzing the data of 862 participants with schizophrenia-spectrum and bipolar disorders (mean [SD] age, 41.9 [12.48] years; 44.8% female) from a multicenter study (PsyCourse Study). Z-scores for three cognitive domains were calculated, global functioning was measured with the Global Assessment of Functioning Scale, and adherence was assessed by a self-rating questionnaire. We evaluated four multiple linear regression models and built three clusters with hierarchical cluster analyses. Higher adherence behavior (p < 0.001) was associated with better global functioning but showed no impact on the cognitive domains learning and memory, executive function, and psychomotor speed. The hierarchical cluster analysis resulted in three clusters with different cognitive performances, but patients in all clusters showed similar adherence behavior. The study identified cognitive subgroups independent of diagnoses, but no differences were found in the adherence behavior of the patients in these new clusters. In summary, medication adherence was associated with global but not cognitive functioning in patients with schizophrenia-spectrum and bipolar disorders. In both diagnostic groups, cognitive function might be influenced by various factors but not medication adherence.

引用

页数：10

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