Depression and anxiety in older adults with cancer: Systematic review and meta-summary of risk, protective and exacerbating factors

被引:33
作者
Lee, Ainsley Ryan Yan Bin [1 ]
Leong, Ivan [1 ]
Lau, Grace [1 ]
Tan, Amanda Weiling [2 ]
Ho, Roger Chun Man [3 ]
Ho, Cyrus Su Hui [3 ]
Chen, Matthew Zhixuan [4 ,5 ]
机构
[1] Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore, Singapore
[2] Natl Univ Singapore, Alice Lee Ctr Nursing Studies, Yong Loo Lin Sch Med, Singapore, Singapore
[3] Natl Univ Singapore, Dept Psychol Med, Singapore, Singapore
[4] Natl Univ Singapore Hosp, Dept Med, Div Geriatr Med, Singapore, Singapore
[5] Natl Univ Hlth Syst, Dept Med, 1E Kent Ridge Rd,NUHS Tower Block, Singapore 119228, Singapore
关键词
Depression; Anxiety; Oncology; Supportive care in oncology; Geriatric oncology; Psychosocial oncology; QUALITY-OF-LIFE; ANDROGEN DEPRIVATION THERAPY; GERIATRIC-PATIENTS; ELDERLY-PATIENTS; PSYCHOLOGICAL DISTRESS; COLORECTAL-CANCER; SYMPTOMS; BREAST; HEALTH; DIAGNOSIS;
D O I
10.1016/j.genhosppsych.2023.01.008
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Objective: To systematically evaluate the risk factors of depression and anxiety in older adults with cancer. Method: This PRISMA-adherent systematic review (PROSPERO CRD42022372747) involved a systematic data-base search for prospective and retrospective cohort studies. Results: We included 33 cohort studies with 31 evaluating depression and seven evaluating anxiety. Systematic synthesis yielded various protective and exacerbating factors for depression and anxiety amongst older adults with cancer. These factors span a range of domains: (1) Cancer and associated treatment-related factors; (2) Medical, physical and functional factors; (3) Demographic factors and; (4) Social and lifestyle factors. At the individual-level, the most significant factors were the presence of chronic medical comorbidities, having pre-existing psychological symptoms, and poor baseline physical and functional status. Within the social unit, the degree of social support and presence of a partner were most significant. Conclusion: The deleterious impact comorbid psychological symptoms can have on older adults with cancer can be profound. In this review, we highlight a range of protective and exacerbating factors identified from cohort studies that may enable policymakers to tailor and individualise interventions to manage depression, anxiety and associated burden in this vulnerable population. The relative paucity of studies evaluating anxiety highlights an important research gap.
引用
收藏
页码:32 / 42
页数:11
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