Nucleotide metabolism regulates human telomere length via telomerase activation

被引：4

作者：

Bryan, Tracy M. ^{[1
]}

机构：

[1] Univ Sydney, Childrens Med Res Inst, Fac Med & Hlth, Westmead, Australia

来源：

NATURE GENETICS | 2023年 / 55卷 / 04期

关键词：

GENOME-WIDE SCREEN; GENES;

D O I：

10.1038/s41588-023-01359-1

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Telomere length is an important determinant of cellular aging and disease risk, but the genetics of telomere length control in humans is unclear. A genome-wide CRISPR screen has now identified a central role for thymidine nucleotide metabolism in the regulation of telomere length, which has implications for the diagnosis and treatment of disease.

引用

页码：532 / 533

页数：2

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