Palladium-Catalyzed C-H Allylation/Annulation Reaction of Amides and Allylic Alcohols: Regioselective Construction of Vinyl-Substituted 3,4-Dihydroisoquinolones

被引：6

作者：

Wu, Haijian ^{[1
,2
]}

Gui, Jing ^{[1
,2
]}

Sun, Manman ^{[1
,2
]}

Ma, Yongmin ^{[1
,2
]}

Yang, Jianguo ^{[1
,2
]}

Wang, Zhiming ^{[1
,2
]}

机构：

[1] Taizhou Univ, Adv Res Inst, Jiaojiang 318000, Zhejiang, Peoples R China

[2] Taizhou Univ, Sch Pharmaceut Sci, Jiaojiang 318000, Zhejiang, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 88卷 / 06期

关键词：

ONE-POT; ASYMMETRIC-SYNTHESIS; DIRECTING-GROUP; ALKYLATION; ALLYLATION; FUNCTIONALIZATION; ACTIVATION; ANNULATION; INDOLES; ACCESS;

D O I：

10.1021/acs.joc.3c00124

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A palladium-catalyzed highly regioselective C-H allylation/annulation reaction of N-sulfonyl amides with secondary or tertiary allylic alcohols has been developed to construct 3,4-dihydroisoquinolones bearing a synthetically valuable vinyl substituent. This cascade cyclization approach of allylic alcohols involving C-H allylation has not been reported previously. The commercially available allylic alcohol substrates, the only by-product of water, and the used terminal oxidant of O2 provide environmentally benign advantages.

引用

页码：3871 / 3882

页数：12

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