Efficient and green synthesis of novel hexahydro-5H-thiazolo[2′,3′:2,3]pyrimido[4,5-b]quinoline derivatives

被引：5
|
作者：
Tabibi, Tooba [1 ]
Esmaeili, Abbas Ali [1 ]
机构：
[1] Ferdowsi Univ Mashhad, Fac Sci, Dept Chem, POB 9177948974, Mashhad, Razavi Khorasan, Iran
来源：
MOLECULAR DIVERSITY | 2023年 / 27卷 / 01期
关键词：
Three-component reaction; Catalyst-free synthesis; 5-Amino-2,3-dihydro-7H-thiazolo [3,2-alpha]pyrimidin-7-one; Hexahydro-5H-thiazolo[2 ',3 ':2,3]pyrimido[4,5-b]quinolines; MICROWAVE-ASSISTED SYNTHESIS; BIOLOGICAL EVALUATION; THIAZOLOPYRIMIDINE DERIVATIVES; PYRIMIDINE; 1,4-DIHYDROPYRIDINES; THIOPYRIMIDINE; ANTIBACTERIAL; INHIBITION; LIGANDS;
D O I：
10.1007/s11030-022-10439-z
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Herein, we report a catalyst-free, one-pot three-component reaction of 5-amino-2,3-dihydro-7H-thiazolo[3,2-a]pyrimidin-7-one, aromatic aldehyde, and dimedone in ethylene glycol as a green solvent at 100 degrees C for the easy access of hexahydro-5H-thiazolo[2',3':2,3]pyrimido[4,5-b]quinoline. Catalyst-free, green solvent, simple procedure, mild reaction conditions, easy work-up procedure, and good to excellent yields are the significant advantages of this protocol. [GRAPHICS] .
引用
收藏
页码：477 / 486
页数：10
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