Hyperpolarized Xenon-129 Chemical Exchange Saturation Transfer (HyperCEST) Molecular Imaging: Achievements and Future Challenges

被引:8
作者
Batarchuk, Viktoriia [1 ,2 ]
Shepelytskyi, Yurii [1 ,2 ]
Grynko, Vira [2 ,3 ]
Kovacs, Antal Halen [4 ]
Hodgson, Aaron [5 ]
Rodriguez, Karla [1 ]
Aldossary, Ruba [2 ]
Talwar, Tanu [1 ]
Hasselbrink, Carson [6 ]
Ruset, Iulian C. [7 ]
DeBoef, Brenton [8 ]
Albert, Mitchell S. [1 ,2 ,9 ]
机构
[1] Lakehead Univ, Chem Dept, Thunder Bay, ON P7B 5E1, Canada
[2] Thunder Bay Reg Hlth Res Inst, Thunder Bay, ON P7B 6V4, Canada
[3] Lakehead Univ, Chem & Mat Sci Program, Thunder Bay, ON P7B 5E1, Canada
[4] Lakehead Univ, Appl Life Sci Program, Thunder Bay, ON P7B 5E1, Canada
[5] Lakehead Univ, Phys Dept, Thunder Bay, ON P7B 5E1, Canada
[6] Calif Polytech State Univ San Luis Obispo, Chem & Biochem Dept, San Luis Obispo, CA 93407 USA
[7] Xemed LCC, Durham, NH 03824 USA
[8] Univ Rhode Isl, Dept Chem, Kingston, RI 02881 USA
[9] Fac Med Sci, Northern Ontario Sch Med, Thunder Bay, ON P7B 5E1, Canada
基金
加拿大自然科学与工程研究理事会;
关键词
molecular imaging; xenon; NMR; hyperpolarized MRI; chemical exchange saturation transfer; biosensors; HyperCEST; personalized medicine; DYNAMIC NUCLEAR-POLARIZATION; CRYPTOPHANE-XENON COMPLEXES; MAGNETIC-RESONANCE; CONTRAST AGENTS; CUCURBITURIL HOMOLOGS; IN-VIVO; NMR; MRI; BIOSENSOR; PROTON;
D O I
10.3390/ijms25031939
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Molecular magnetic resonance imaging (MRI) is an emerging field that is set to revolutionize our perspective of disease diagnosis, treatment efficacy monitoring, and precision medicine in full concordance with personalized medicine. A wide range of hyperpolarized (HP) 129Xe biosensors have been recently developed, demonstrating their potential applications in molecular settings, and achieving notable success within in vitro studies. The favorable nuclear magnetic resonance properties of 129Xe, coupled with its non-toxic nature, high solubility in biological tissues, and capacity to dissolve in blood and diffuse across membranes, highlight its superior role for applications in molecular MRI settings. The incorporation of reporters that combine signal enhancement from both hyperpolarized 129Xe and chemical exchange saturation transfer holds the potential to address the primary limitation of low sensitivity observed in conventional MRI. This review provides a summary of the various applications of HP 129Xe biosensors developed over the last decade, specifically highlighting their use in MRI. Moreover, this paper addresses the evolution of in vivo applications of HP 129Xe, discussing its potential transition into clinical settings.
引用
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页数:37
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