Bioactive constituents from Trichilia dregeana Sond. (Meliaceae)

被引：3

作者：

Tatio, Laurel Flairon Fotso ^{[1
]}

Bissoue, Achille Nouga ^{[1
]}

Tcho, Alain Tadjong ^{[2
]}

Akone, Sergi Herve ^{[1
,3
]}

Jounda, Nadege Nelly ^{[4
]}

Tsopgni, Willifred Dongmo Tekapi ^{[1
]}

Waffo, Alain Francois Kamdem ^{[1
]}

机构：

[1] Univ Douala, Fac Sci, Dept Chem, Chem Lab, Douala, Cameroon

[2] Univ Buea, Fac Sci, Dept Chem, Buea, Cameroon

[3] Univ Saarland, Helmholtz Inst Pharmaceut Res Saarland HIPS, Dept Microbial Nat Prod MINS, Saarbrucken, Germany

[4] Univ Douala, Dept Chem Engn, Proc Engn Lab, HTTTC, Douala, Cameroon

来源：

NATURAL PRODUCT RESEARCH | 2025年 / 39卷 / 05期

关键词：

Trichilia dregeana; meliaceae; cycloartane-type triterpene; antibacterial activity; antifungal activity; antioxidant potential; CHEMICAL-CONSTITUENTS; BARK; MAHOGANY; EXTRACTS; LEAVES; ROOTS;

D O I：

10.1080/14786419.2023.2297254

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The chemical investigation of the methanolic leaf extract of Trichilia dregeana Sond. led to the isolation of a hitherto unreported cycloartane-type triterpene, dregeanol (1), together with nine known compounds, (3 beta,23E)-9,19-cyclolanosta-23,25-dien-3-ol (2), 9,19-cyclolanost-24-en-23-one (3), 6 beta-hydroxystigmasta-4,22-dien-3-one (4), lyoniresinol (5), maslinic acid (6), asperphernamate (7), mixture of stigmasterol (8) and beta-sitosterol (9) and beta-sitosterol-3-O-beta-D-glucopyranoside (10). The structures of the isolates were elucidated by extensive spectroscopic and spectrometric analyses (1D and 2D NMR, ESI-MS) and by comparison with previously reported data. Compounds 2 and 6 showed significant antibacterial effect against Escherichia coli and Salmonella enteritidis, res-pectively, with MIC value of 31.25 mu g/mL, whilst they displayed moderate antifungal effect with MIC value of 62.5 mu g/mL against Candida albicans. All the isolates except compound 3 were found to possess a weak antioxidant potential in the DPPH, ABTS and FRAP assays.

引用

页码：1139 / 1149

页数：11

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