Recent advances in polymeric microparticle-based drug delivery systems for knee osteoarthritis treatment

被引：4
|
作者：
Wang, Guangxin [1 ]
Zhang, Xin-an [2 ]
Kapilevich, Leonid [3 ]
Hu, Mingjie [2 ]
机构：
[1] Fourth Peoples Hosp Shenyang, Dept Orthoped, Shenyang, Peoples R China
[2] Shenyang Sport Univ, Coll Exercise & Hlth, Shenyang, Peoples R China
[3] Nаtl Res Tomsk Stаte Univ, Fac Phys Educ, Tomsk, Russia
来源：
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY | 2023年 / 11卷
基金：
中国国家自然科学基金;
关键词：
knee osteoarthritis; drug delivery systems; intra-articular; microparticles; biodegradable polymers; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; INTRAARTICULAR INJECTION; TRIAMCINOLONE ACETONIDE; GLOBAL BURDEN; MICROSPHERE FORMULATION; LOADED MICROPARTICLES; CONTROLLED-RELEASE; NATIONAL INCIDENCE; SYNOVIAL-FLUID; 195; COUNTRIES;
D O I：
10.3389/fbioe.2023.1290870
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Due to the poor bioavailability and high joint clearance of drugs, sustained delivery of therapeutic agents has proven difficult in the treatment of osteoarthritis (OA). Intra-articular (IA) drug delivery strategy is an attractive option for enhancing OA patients' prognosis, for which various polymer materials have been used as drug carriers due to their attractive delivery properties, to slow or even reverse the progress of OA by prolonging the duration of therapeutic agent residence in the joint. This article focuses on the recent developments in natural and synthetic polymer-based microsphere drug delivery systems for treating knee osteoarthritis. It evaluates the translational potential of some novel formulations for clinical application.
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页数：14
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