The generation and use of animal models of osteosarcoma in cancer research

被引：8

作者：

Pu, Feifei ^{[1
,2
]}

Guo, Haoyu ^{[2
]}

Shi, Deyao ^{[2
]}

Chen, Fengxia ^{[3
,4
]}

Peng, Yizhong ^{[2
]}

Huang, Xin ^{[2
]}

Liu, Jianxiang ^{[2
]}

Zhang, Zhicai ^{[2
]}

Shao, Zengwu ^{[2
]}

机构：

[1] Huazhong Univ Sci & Technol, Wuhan Hosp Tradit Chinese & Western Med, Wuhan Hosp 1, Tongji Med Coll,Dept Orthoped, Wuhan 430022, Hubei, Peoples R China

[2] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Orthoped, Wuhan 430022, Hubei, Peoples R China

[3] Wuhan Univ, Zhongnan Hosp, Dept Radiat & Med Oncol, Wuhan 430071, Hubei, Peoples R China

[4] Wuhan Univ, Zhongnan Hosp, Hubei Canc Clin Study Ctr, Wuhan 430071, Hubei, Peoples R China

来源：

GENES & DISEASES | 2024年 / 11卷 / 02期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

Animal model; Cancer; Osteosarcoma; Pathogenic mechanism; Translational research; VIRUS-INDUCED OSTEOSARCOMA; CANINE OSTEOSARCOMA; SPONTANEOUS METASTASIS; MOUSE MODEL; ORTHOTOPIC TRANSPLANTATION; PULMONARY METASTASIS; MURINE OSTEOSARCOMA; TUMOR-SUPPRESSOR; XENOGRAFT MODEL; CELL-LINES;

D O I：

10.1016/j.gendis.2022.12.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Osteosarcoma is the most common malignant bone tumor affecting children and adolescents. Currently, the most common treatment is surgery combined with neoadjuvant chemotherapy. Although the survival rate of patients with osteosarcoma has improved in recent years, it remains poor when the tumor(s) progress and distant metastases develop. Therefore, better animal models that more accurately replicate the natural progression of the disease are needed to develop improved prognostic and diagnostic markers, as well as targeted therapies for both primary and metastatic osteosarcoma. The present review described animal models currently being used in research investigating osteosarcoma, and their characteristics, advantages, and disadvantages. These models may help elucidate the pathogenic mechanism(s) of osteosarcoma and provide evidence to support and develop clinical treatment strategies.

引用

页码：664 / 674

页数：11

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