RetroBioCat Database: A Platform for Collaborative Curation and Automated Meta-Analysis of Biocatalysis Data

被引：19

作者：

Finnigan, William ^{[1
]}

Lubberink, Max ^{[1
,2
]}

Hepworth, Lorna J. ^{[1
]}

Citoler, Joan ^{[1
]}

Mattey, Ashley P. ^{[1
]}

Ford, Grayson J. ^{[1
]}

Sangster, Jack ^{[1
]}

Cosgrove, Sebastian C. ^{[1
,3
]}

da Costa, Bruna Zucoloto ^{[1
]}

Heath, Rachel S. ^{[1
]}

Thorpe, Thomas W. ^{[1
,4
]}

Yu, Yuqi ^{[1
]}

Flitsch, Sabine L. ^{[1
]}

Turner, Nicholas J. ^{[1
]}

机构：

[1] Univ Manchester, Manchester Inst Biotechnol, Dept Chem, 131 Princess St, Manchester M1 7DN, England

[2] Wageningen Food & Biobased Res, POB 17, NL-6700AA Wageningen, Netherlands

[3] Keele Univ, Sch Chem & Phys Sci, Lennard Jones Lab, Keele ST5 5BG, Staffs, England

[4] Univ Edinburgh, Inst Quantitat Biol Biochem & Biotechnol, Sch Biol Sci, Kings Bldg,Alexander Crum Brown Rd, Edinburgh EH9 3FF, Midlothian, Scotland

来源：

ACS CATALYSIS | 2023年 / 13卷 / 17期

基金：

欧盟地平线“2020”; 欧洲研究理事会;

关键词：

biocatalysis; database; enzyme selection; visualization; synthesis planning; ENZYMES;

D O I：

10.1021/acscatal.3c01418

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Despite the increasinguseof biocatalysis for organic synthesis, there are currently no databasesthat adequately capture synthetic biotransformations. The lack ofa biocatalysis database prevents accelerating biocatalyst characterizationefforts from being leveraged to quickly identify candidate enzymesfor reactions or cascades, slowing their development. The RetroBioCatDatabase (available at retrobiocat.com) addresses this gap by capturing information on synthetic biotransformationsand providing an analysis platform that allows biocatalysis data tobe searched and explored through a range of highly interactive datavisualization tools. This database makes it simple to explore availableenzymes, their substrate scopes, and how characterized enzymes arerelated to each other and the wider sequence space. Data entry isfacilitated through an openly accessible curation platform, featuringautomated tools to accelerate the process. The RetroBioCat Databasedemocratizes biocatalysis knowledge and has the potential to acceleratebiocatalytic reaction development, making it a valuable resource forthe community.

引用

页码：11771 / 11780

页数：10

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