Optimal treatment strategy and prognostic analysis for hypopharyngeal squamous-cell carcinoma patients with T3-T4 or node-positive: A population-based study

被引:1
|
作者
Zheng, Linhui [1 ]
Fang, Sha [1 ]
Ye, Linfeng [2 ]
Cai, Wenqi [1 ]
Xiang, Wenbin [1 ]
Qi, Yan [1 ]
Wu, Huachao [1 ]
Yang, Chunqian [1 ]
Zhang, Runze [1 ]
Liu, Yifeng [1 ]
Liu, Yue [1 ]
Wu, Chaoyan [5 ,6 ]
Yu, Haijun [3 ,4 ,6 ]
机构
[1] Wuhan Univ, Zhongnan Hosp, Dept Radiat & Med Oncol, Wuhan 430071, Peoples R China
[2] Wuhan Univ, Zhongnan Hosp, Dept Otorhinolaryngol Head & Neck Surg, Wuhan 430071, Peoples R China
[3] Wuhan Univ, Zhongnan Hosp, Hubei Canc Clin Study Ctr, Wuhan 430071, Peoples R China
[4] Hubei Key Lab Tumor Biol Behav, Wuhan 430071, Peoples R China
[5] Wuhan Univ, Zhongnan Hosp, Dept Integrated Tradit Chinese Med & Western Med, Wuhan 430071, Peoples R China
[6] 169 Donghu Rd, Wuhan 430071, Hubei, Peoples R China
来源
EJSO | 2023年 / 49卷 / 07期
基金
中国国家自然科学基金;
关键词
Hypopharyngeal neoplasms; Lymph node metastasis; Optimal treatment strategy; SEER; External validation; DEFINITIVE CHEMORADIOTHERAPY; ADJUVANT RADIOTHERAPY; LARYNX PRESERVATION; NECK-CANCER; HEAD; CHEMOTHERAPY; SURGERY; SURVIVAL; TRENDS;
D O I
10.1016/j.ejso.2023.03.215
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose: To explore the optimal treatment strategy and relevant prognostic analysis for hypopharyngeal squamous-cell carcinoma patients (HSCC) with T3-T4 or node-positive. Methods and materials: From 2004 to 2018, data for 2574 patients from the Surveillance, Epidemiology, and End Results database (SEER) and 66 patients treated at our center from 2013 to 2022 with T3-T4 or N + HSCC were collected. Patients in the SEER cohort were randomly assigned to the training set or validation set at a 7:3 ratio. Variables with statistically significant (P < 0.05) in univariate COX regression analysis or clinical significance were included in the multivariate COX regression model and subsequently used to construct the nomogram. Results: The 3-year OS (52.9%vs44.4%, P < 0.01) and 3-year CSS rate (58.7%vs51.5%, P < 0.01) rates in the surgery combined with postoperative adjuvant therapy (S + ADT) group were superior to the radiotherapy combined with chemotherapy (CRT) group. The multivariate Cox regression analysis of the training group showed that age, race, marital status, primary site, T stage, N stage, and treatment modalities were correlated with OS and CSS. Based on those variables, we constructed nomograms for OS and CSS. Both the internal and external validation showed high prediction accuracy of the nomogram. Conclusion: Among patients with T3-T4 or node-positive, S + ADT was associated with superior OS and CSS compared to those treated with primary CRT, while the survival rate in the CRT group was comparable to S + ADT group in T2-T3 disease. The internal and external verification shows that the prognostic model has good discrimination ability and accuracy.& COPY; 2023 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
引用
收藏
页码:1162 / 1170
页数:9
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