How organoids can improve personalized treatment in patients with gastro-esophageal tumors

被引：7

作者：

Cabeza-Segura, Manuel ^{[1
]}

Garcia-Mico, Blanca ^{[1
]}

La Noce, Marcella ^{[2
]}

Nicoletti, Giovanni Francesco ^{[3
]}

Conti, Valeria ^{[4
,5
]}

Filippelli, Amelia ^{[4
,5
]}

Fleitas, Tania ^{[1
,6
]}

Cervantes, Andres ^{[1
,6
]}

Castillo, Josefa ^{[1
,6
,7
]}

Papaccio, Federica ^{[1
,4
]}

机构：

[1] Univ Valencia, Hosp Clin Univ, Biomed Res Inst INCLIVA, Dept Med Oncol, Valencia, Spain

[2] Univ Campania L Vanvitelli, Dept Expt Med, Sect Biotechnol Mol Med & Med Histol, Via L de Crecchio 7, I-80138 Naples, Italy

[3] Univ Campania L Vanvitelli, Multidisciplinary Dept Med Surg & Dent Specialtie, Via L de Crecchio 6, I-80138 Naples, Italy

[4] Univ Salerno, Scuola Med Salernitana, Dept Med Surg & Dent, Baronissi, SA, Italy

[5] San Giovanni Dio & Ruggi DAragona Univ Hosp, Pharmacol Unit, Salerno, Italy

[6] Inst Salud Carlos III, Ctr Invest Biomed Red CIBERONC, Madrid 28029, Spain

[7] Univ Valencia, Dept Biochem & Mol Biol, Valencia, Spain

来源：

CURRENT OPINION IN PHARMACOLOGY | 2023年 / 69卷

关键词：

CLINICAL-PRACTICE GUIDELINE; CANCER; ESOPHAGEAL; CHEMOTHERAPY; DIVERSITY; CARCINOMA; DIAGNOSIS; MEDICINE; BIOBANK; MODELS;

D O I：

10.1016/j.coph.2023.102348

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Gastro-esophageal tumors constitute a big health problem. Treatment options still mainly rely on chemotherapy, and apart from human epidermal growth factor receptor 2 positive and microsatellite instable/Epstein-Barr Virus disease, there are no molecularly guided options. Therefore, despite the large number of identified molecular alterations, precision medicine is still far from the clinic. In this context, the recently developed technology of patient-derived organoids (PDOs) could offer the chance to accelerate drug development and biomarker dis-covery. Indeed, PDOs are 3D primary cultures that were shown to reproduce patient's tumor characteristics. Moreover, several reports indicated that PDOs can replicate patient's response to a given drug; therefore, they are one of the most promising tools for functional precision medicine.

引用

页数：7

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