Meta-hallmarks of aging and cancer

被引：290

作者：

Lopez-Otin, Carlos ^{[1
,2
,3
]}

Pietrocola, Federico ^{[4
]}

Roiz-Valle, David ^{[1
]}

Galluzzi, Lorenzo ^{[5
,6
,7
]}

Kroemer, Guido ^{[8
,9
,10
]}

机构：

[1] Univ Oviedo, Inst Univ Oncol IUOPA, Dept Bioquim & Biol Mol, Oviedo, Spain

[2] Inst Invest Sanitaria Principado Asturias ISPA, Oviedo, Spain

[3] Ctr Invest Biomed Red Canc CIBERONC, Madrid, Spain

[4] Karolinska Inst, Dept Biosci & Nutr, Huddinge, Sweden

[5] Weill Cornell Med Coll, Dept Radiat Oncol, New York, NY USA

[6] Sandra & Edward Meyer Canc Ctr, New York, NY USA

[7] Caryl & Israel Englander Inst Precis Med, New York, NY USA

[8] Univ Paris Cite, Sorbonne Univ, Inst Univ France,INSERM,U1138, Ctr Rech Cordeliers,Equipe Labellisee Ligue Canc, Paris, France

[9] Gustave Roussy, Metabol & Cell Biol Platforms, Villejuif, France

[10] Hop Europeen Georges Pompidou, AP HP, Inst Canc Paris CARPEM, Dept Biol, Paris, France

来源：

CELL METABOLISM | 2023年 / 35卷 / 01期

基金：

欧盟地平线“2020”; 欧洲研究理事会; 瑞典研究理事会;

关键词：

FASTING-MIMICKING DIET; CELLULAR SENESCENCE; GUT MICROBIOTA; CLONAL HEMATOPOIESIS; CHRONIC INFLAMMATION; CALORIC RESTRICTION; MAMMARY EPITHELIA; TELOMERE LENGTH; TERT EXPRESSION; BREAST-CANCER;

D O I：

10.1016/j.cmet.2022.11.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Both aging and cancer are characterized by a series of partially overlapping "hallmarks"that we subject here to a meta-analysis. Several hallmarks of aging (i.e., genomic instability, epigenetic alterations, chronic inflammation, and dysbiosis) are very similar to specific cancer hallmarks and hence constitute common "metahallmarks,"while other features of aging (i.e., telomere attrition and stem cell exhaustion) act likely to suppress oncogenesis and hence can be viewed as preponderantly "antagonistic hallmarks."Disabled macroautophagy and cellular senescence are two hallmarks of aging that exert context-dependent oncosuppressive and pro-tumorigenic effects. Similarly, the equivalence or antagonism between aging-associated deregulated nutrient-sensing and cancer-relevant alterations of cellular metabolism is complex. The agonistic and antagonistic relationship between the processes that drive aging and cancer has bearings for the age-related increase and oldest age-related decrease of cancer morbidity and mortality, as well as for the therapeutic management of malignant disease in the elderly.

引用

页码：12 / 35

页数：24

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