As potential candidates for treating ulcerative colitis (UC), polysaccharides have been attracting extensive interest in recent years. Cordyceps sinensis (C. sinensis) is a kind of traditional Chinese edible food, and its polysaccharide fractions have been found to be effective in regulating immunity and protecting the kidneys. To determine the potential function of polysaccharides from natural C. sinensis on UC, their effects in terms of histological, serological, biochemical, and immunological aspects on dextran sulphate sodium (DSS)-induced colitis mice model were investigated. Results showed that the polysaccharides significantly alleviated colitis by increasing the colon length, alleviating colon tissue damage, and inhibiting the activation of the NF-kappa B pathway. In addition, polysaccharides reduced the contents of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) in the serum, increased the number of goblet cells, and improved the expression of intestinal tight junction proteins (Occludin and Claudin-1). They also evidently enhanced the formation of IgA-secretory cells and sIgA contents. Furthermore, the polysaccharides modulated the gut microbiota by decreasing the relative abundance of Bilophila and increasing the relative abundance of Dehalobacterium, Coprococcus, Oscillospira, and Desulfovibrio, which is accompanied by an increase in the short chain fatty acids' (SCFAs) concentrations in cecal contents. These results suggested that C. sinensis polysaccharides possessed promising intervening effects on experimental acute UC in mice.
机构:
Jozef Stefan Inst, Dept Biotechnol, Jamova 39, SI-1000 Ljubljana, SloveniaJozef Stefan Inst, Dept Biotechnol, Jamova 39, SI-1000 Ljubljana, Slovenia
Berlec, Aies
Perse, Martina
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Univ Ljubljana, Fac Med, Ctr Med Expt, Inst Pathol, Zaloska 4, Ljubljana 1000, SloveniaJozef Stefan Inst, Dept Biotechnol, Jamova 39, SI-1000 Ljubljana, Slovenia
Perse, Martina
Ravnikar, Matjaz
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Univ Ljubljana, Fac Pharm, Askerceva 7, Ljubljana 1000, SloveniaJozef Stefan Inst, Dept Biotechnol, Jamova 39, SI-1000 Ljubljana, Slovenia
Ravnikar, Matjaz
Lunder, Mojca
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Univ Ljubljana, Fac Pharm, Askerceva 7, Ljubljana 1000, SloveniaJozef Stefan Inst, Dept Biotechnol, Jamova 39, SI-1000 Ljubljana, Slovenia
Lunder, Mojca
Erman, Andreja
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Univ Ljubljana, Fac Med, Inst Cell Biol, Ljubljana 1000, SloveniaJozef Stefan Inst, Dept Biotechnol, Jamova 39, SI-1000 Ljubljana, Slovenia
Erman, Andreja
Cerar, Anton
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Univ Ljubljana, Fac Med, Ctr Med Expt, Inst Pathol, Zaloska 4, Ljubljana 1000, SloveniaJozef Stefan Inst, Dept Biotechnol, Jamova 39, SI-1000 Ljubljana, Slovenia
Cerar, Anton
Strukelj, Borut
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Jozef Stefan Inst, Dept Biotechnol, Jamova 39, SI-1000 Ljubljana, Slovenia
Univ Ljubljana, Fac Pharm, Askerceva 7, Ljubljana 1000, SloveniaJozef Stefan Inst, Dept Biotechnol, Jamova 39, SI-1000 Ljubljana, Slovenia
机构:
Indian Council Med Res, Natl Inst Nutr, Div Food Safety, Jamai Osmania PO, Hyderabad 500007, India
Osmania Univ, Dept Biochem, Hyderabad 500027, Telangana, IndiaIndian Council Med Res, Natl Inst Nutr, Div Food Safety, Jamai Osmania PO, Hyderabad 500007, India
Chougule, Priyanka Raju
Sangaraju, Rajendra
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Indian Council Med Res, Natl Inst Nutr, Div Food Safety, Jamai Osmania PO, Hyderabad 500007, IndiaIndian Council Med Res, Natl Inst Nutr, Div Food Safety, Jamai Osmania PO, Hyderabad 500007, India
Sangaraju, Rajendra
Patil, Pradeep B. B.
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ICMR Natl Inst Nutr, Anim Facil, Jamai Osmania PO, Hyderabad 500007, IndiaIndian Council Med Res, Natl Inst Nutr, Div Food Safety, Jamai Osmania PO, Hyderabad 500007, India
Patil, Pradeep B. B.
Qadri, S. S. Y. H.
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ICMR Natl Inst Nutr, Anim Facil, Jamai Osmania PO, Hyderabad 500007, IndiaIndian Council Med Res, Natl Inst Nutr, Div Food Safety, Jamai Osmania PO, Hyderabad 500007, India
Qadri, S. S. Y. H.
Panpatil, Virendra V. V.
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Natl Inst Nutr ICMR, Mol Biol Div, Hyderabad 500007, IndiaIndian Council Med Res, Natl Inst Nutr, Div Food Safety, Jamai Osmania PO, Hyderabad 500007, India
Panpatil, Virendra V. V.
Ghosh, Sudip
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Natl Inst Nutr ICMR, Mol Biol Div, Hyderabad 500007, IndiaIndian Council Med Res, Natl Inst Nutr, Div Food Safety, Jamai Osmania PO, Hyderabad 500007, India
Ghosh, Sudip
Mungamuri, Sathish Kumar
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Indian Council Med Res, Natl Inst Nutr, Div Food Safety, Jamai Osmania PO, Hyderabad 500007, IndiaIndian Council Med Res, Natl Inst Nutr, Div Food Safety, Jamai Osmania PO, Hyderabad 500007, India
Mungamuri, Sathish Kumar
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Bhanoori, Manjula
Sinha, Sukesh Narayan
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Indian Council Med Res, Natl Inst Nutr, Div Food Safety, Jamai Osmania PO, Hyderabad 500007, IndiaIndian Council Med Res, Natl Inst Nutr, Div Food Safety, Jamai Osmania PO, Hyderabad 500007, India
SONG Lijun ZHAO Wenchang DENG Hongzhu School of Pharmacy Guangdong Medical College Dongguan China School of Traditional Chinese Medicine Southern Medical University Guangzhou China
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SONG Lijun ZHAO Wenchang DENG Hongzhu School of Pharmacy Guangdong Medical College Dongguan China School of Traditional Chinese Medicine Southern Medical University Guangzhou China
机构:
Guangdong Med Coll, Sch Pharm, Dongguan 523808, Peoples R ChinaGuangdong Med Coll, Sch Pharm, Dongguan 523808, Peoples R China
Song Li-jun
Zhao Wen-chang
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Guangdong Med Coll, Sch Pharm, Dongguan 523808, Peoples R ChinaGuangdong Med Coll, Sch Pharm, Dongguan 523808, Peoples R China
Zhao Wen-chang
Deng Hong-zhu
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Southern Med Univ, Sch Tradit Chinese Med, Guangzhou 510515, Guangdong, Peoples R ChinaGuangdong Med Coll, Sch Pharm, Dongguan 523808, Peoples R China