Ageing and multiple sclerosis

被引：120

作者：

Graves, Jennifer S. ^{[1
,2
,3
,11
]}

Krysko, Kristen M. ^{[4
]}

Hua, Le H. ^{[5
]}

Absinta, Martina ^{[6
,7
,8
]}

Franklin, Robin J. M. ^{[9
]}

Segal, Benjamin M. ^{[10
]}

机构：

[1] Univ Calif San Diego, Dept Neurosci, San Diego, CA USA

[2] Rady Childrens Hosp, Pediat Multiple Sclerosis Ctr, San Diego, CA USA

[3] San Diego VA Hosp, Dept Neurol, San Diego, CA USA

[4] Univ Toronto, St Michaels Hosp, Li Ka Shing Knowledge Inst, Dept Med, Toronto, ON, Canada

[5] Cleveland Clin, Dept Neurol, Lou Ruvo Ctr Brain Hlth, Las Vegas, NV USA

[6] Johns Hopkins Univ, Dept Neurol, Baltimore, MD USA

[7] IRCCS San Raffaele Sci Inst, Div Neurosci, Milan, Italy

[8] Univ Vita Salute San Raffaele, Milan, Italy

[9] Univ Cambridge, Wellcome MRC Cambridge Stem Cell Inst, Cambridge, England

[10] Ohio State Univ, Dept Neurol, Columbus, OH USA

[11] Univ Calif San Diego, Dept Neurosci, San Diego, CA 92037 USA

来源：

LANCET NEUROLOGY | 2023年 / 22卷 / 01期

基金：

美国国家卫生研究院; 英国医学研究理事会; 英国惠康基金;

关键词：

GRAY-MATTER VOLUME; REMYELINATION CAPACITY; VASCULAR COMORBIDITY; TELOMERE BIOLOGY; DOUBLE-BLIND; RIM LESIONS; AGE; DISABILITY; BRAIN; MS;

D O I：

10.1016/S1474-4422(22)00184-3

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The factor that is most relevant and strongly associated with the clinical course of multiple sclerosis is chronological age. Very young patients exclusively have relapsing remitting disease, whereas those with later onset disease face a more rapid development of permanent disability. For people with progressive multiple sclerosis, the poor response to current disease modifying therapies might be related to ageing in the immune system and CNS. Ageing is also associated with increased risks of side-effects caused by some multiple sclerosis therapies. Both somatic and reproductive ageing processes might contribute to development of progressive multiple sclerosis. Understanding the role of ageing in immune and neural cell function in patients with multiple sclerosis might be key to halting non -relapse-related progression. The growing literature on potential therapies that target senescent cells and ageing processes might provide effective strategies for remyelination and neuroprotection.

引用

页码：66 / 77

页数：12

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