Report of the APOE4 National Institute on Aging/Alzheimer Disease Sequencing Project Consortium Working Group: Reducing APOE4 in Carriers is a Therapeutic Goal for Alzheimer's Disease

被引：16

作者：

Vance, Jeffery M. ^{[1
]}

Farrer, Lindsay A. ^{[2
,3
,4
,5
,6
]}

Huang, Yadong ^{[7
]}

Cruchaga, Carlos ^{[8
]}

Hyman, Bradley T. ^{[9
]}

Pericak-Vance, Margaret A. ^{[1
]}

Goate, Alison M. ^{[10
,11
]}

Greicius, Michael D. ^{[12
]}

Griswold, Anthony J. ^{[13
]}

Haines, Jonathan L. ^{[14
]}

Julia, T. C. W. ^{[15
,16
,17
]}

Schellenberg, Gerard D. ^{[18
]}

Tsai, Li-Huei ^{[19
]}

Herz, Joachim ^{[20
,21
,22
]}

Holtzman, David M. ^{[23
]}

机构：

[1] Univ Miami, John P Hussman Inst Human Genom, Miller Sch Med, John T McDonald Dept Human Genet, Miami, FL USA

[2] Boston Univ, Dept Med Biomed Genet, Chobanian & Avedisian Sch Med, Boston, MA USA

[3] Boston Univ, Dept Neurol, Chobanian & Avedisian Sch Med, Boston, MA USA

[4] Boston Univ, Dept Ophthalmol, Chobanian & Avedisian Sch Med, Boston, MA USA

[5] Boston Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA USA

[6] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA

[7] Univ Calif San Francisco, Gladstone Inst Neurol Dis, Gladstone Ctr Translat Advancement, Dept Neurol, San Francisco, CA USA

[8] Washington Univ St Louis, Dept Psychiat, St Louis, MO USA

[9] Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurol, Alzheimer Res Unit,Inst Neurodegenerat Dis, Boston, MA USA

[10] Icahn Sch Med Mt Sinai, Ronald M Loeb Ctr Alzheimers Dis, Dept Genet, New York, NY USA

[11] Icahn Sch Med Mt Sinai, Ronald M Loeb Ctr Alzheimers Dis, Dept Genom Sci, New York, NY USA

[12] Stanford Univ, Dept Neurol & Neurol Sci, Sch Med, Stanford, CA USA

[13] Univ Miami, Dr John T Macdonald Fdn, John P Hussman Inst Human Genom, Miller Sch Med,Dept Human Genet, Miami, FL USA

[14] Case Western Reserve Univ, Dept Populat & Quantitat Hlth Sci, Cleveland, OH USA

[15] Chobanian & Avedisian Sch Med, Dept Pharmacol, Boston, MA USA

[16] Chobanian & Avedisian Sch Med, Dept Physiol & Biophys, Boston, MA USA

[17] Boston Univ, Fac Comp & Data Sci, Bioinformat Program, Boston, MA USA

[18] Univ Penn, Perelman Sch Med, Dept Pathol & Lab Med, Philadelphia, PA USA

[19] MIT, Dept Brain & Cognit Sci, Picower Inst Learning & Memory, Cambridge, MA USA

[20] UT Southwestern, Dept Mol Genet, Ctr Translat Neurodegenerat Res, Dallas, TX USA

[21] UT Southwestern, Dept Neurosci, Ctr Translat Neurodegenerat Res, Dallas, TX USA

[22] UT Southwestern, Dept Neurol, Ctr Translat Neurodegenerat Res, Dallas, TX USA

[23] Washington Univ St Louis, Dept Neurol, Hope Ctr Neurol Disorders, Knight Alzheimers Dis Res Ctr, St Louis, MO USA

来源：

ANNALS OF NEUROLOGY | 2024年 / 95卷 / 04期

关键词：

TAU-MEDIATED NEURODEGENERATION; APOLIPOPROTEIN-E GENOTYPE; A-BETA ACCUMULATION; MOUSE MODEL; AMYLOID DEPOSITION; PLAQUE-FORMATION; TYPE-4; ALLELE; RISK; AGE; ASSOCIATION;

D O I：

10.1002/ana.26864

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Alzheimer's disease (AD) is the most common neurodegenerative disorder and one of the leading causes of disability worldwide. The apolipoprotein E4 gene (APOE4) is the strongest genetic risk factor for AD. In 2023, the APOE4 National Institute on Aging/Alzheimer's Disease Sequencing Project working group came together to gather data and discuss the question of whether to reduce or increase APOE4 as a therapeutic intervention for AD. It was the unanimous consensus that cumulative data from multiple studies in humans and animal models support that lowering APOE4 should be a target for therapeutic approaches for APOE4 carriers. ANN NEUROL 2024

引用

页码：625 / 634

页数：10

共 74 条

[31] Common Variants in Psychiatric Risk Genes Predict Brain Structure at Birth [J].

Knickmeyer, Rebecca C. ;

Wang, Jiaping ;

Zhu, Hongtu ;

Geng, Xiujuan ;

Woolson, Sandra ;

Hamer, Robert M. ;

Konneker, Thomas ;

Lin, Weili ;

Styner, Martin ;

Gilmore, John H. .

CEREBRAL CORTEX, 2014, 24 (05) :1230-1246

[32] Neuronal APOE4 removal protects against tau-mediated gliosis, neurodegeneration and myelin deficits [J].

Koutsodendris, Nicole ;

Blumenfeld, Jessica ;

Agrawal, Ayushi ;

Traglia, Michela ;

Grone, Brian ;

Zilberter, Misha ;

Yip, Oscar ;

Rao, Antara ;

Nelson, Maxine R. ;

Hao, Yanxia ;

Thomas, Reuben ;

Yoon, Seo Yeon ;

Arriola, Patrick ;

Huang, Yadong .

NATURE AGING, 2023, 3 (03) :275-+

[33] Association of Rare APOE Missense Variants V236E and R251G With Risk of Alzheimer Disease [J].

Le Guen, Yann ;

Belloy, Michael E. ;

Grenier-Boley, Benjamin ;

de Rojas, Itziar ;

Castillo-Morales, Atahualpa ;

Jansen, Iris ;

Nicolas, Aude ;

Bellenguez, Celine ;

Dalmasso, Carolina ;

Kucukali, Fahri ;

Eger, Sarah J. ;

Rasmussen, Katrine Laura ;

Thomassen, Jesper Qvist ;

Deleuze, Jean-Francois ;

He, Zihuai ;

Napolioni, Valerio ;

Amouyel, Philippe ;

Jessen, Frank ;

Kehoe, Patrick G. ;

van Duijn, Cornelia ;

Tsolaki, Magda ;

Sanchez-Juan, Pascual ;

Sleegers, Kristel ;

Ingelsson, Martin ;

Rossi, Giacomina ;

Hiltunen, Mikko ;

Sims, Rebecca ;

van der Flier, Wiesje M. ;

Ramirez, Alfredo ;

Andreassen, Ole A. ;

Frikke-Schmidt, Ruth ;

Williams, Julie ;

Ruiz, Agustin ;

Lambert, Jean-Charles ;

Greicius, Michael D. .

JAMA NEUROLOGY, 2022, 79 (07) :652-663

[34] Faulty autolysosome acidification in Alzheimer's disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques [J].

Lee, Ju-Hyun ;

Yang, Dun-Sheng ;

Goulbourne, Chris N. ;

Im, Eunju ;

Stavrides, Philip ;

Pensalfini, Anna ;

Chan, Han ;

Bouchet-Marquis, Cedric ;

Bleiwas, Cynthia ;

Berg, Martin J. ;

Huo, Chunfeng ;

Peddy, James ;

Pawlik, Monika ;

Levy, Efrat ;

Rao, Mala ;

Staufenbiel, Mathias ;

Nixon, Ralph A. .

NATURE NEUROSCIENCE, 2022, 25 (06) :688-+

[35] Suppression of vacuolar-type ATPase and induction of endoplasmic reticulum stress by proton pump inhibitors [J].

Lee, Wei-Ping .

JOURNAL OF THE CHINESE MEDICAL ASSOCIATION, 2022, 85 (09) :915-921

[36] Apolipoprotein E4 Reduction with Antisense Oligonucleotides Decreases Neurodegeneration in a Tauopathy Model [J].

Litvinchuk, Alexandra ;

Huynh, Tien-Phat, V ;

Shi, Yang ;

Jackson, Rosemary J. ;

Finn, Mary B. ;

Manis, Melissa ;

Francis, Caroline M. ;

Tran, Ainsley C. ;

Sullivan, Patrick M. ;

Ulrich, Jason D. ;

Hyman, Bradley T. ;

Cole, Tracy ;

Holtzman, David M. .

ANNALS OF NEUROLOGY, 2021, 89 (05) :952-966

[37] ApoE4 Accelerates Early Seeding of Amyloid Pathology [J].

Liu, Chia-Chen ;

Zhao, Na ;

Fu, Yuan ;

Wang, Na ;

Linares, Cynthia ;

Tsai, Chih-Wei ;

Bu, Guojun .

NEURON, 2017, 96 (05) :1024-+

[38] Selective reduction of astrocyte apoE3 and apoE4 strongly reduces Aβ accumulation and plaque-related pathology in a mouse model of amyloidosis [J].

Mahan, Thomas E. ;

Wang, Chao ;

Bao, Xin ;

Choudhury, Ankit ;

Ulrich, Jason D. ;

Holtzman, David M. .

MOLECULAR NEURODEGENERATION, 2022, 17 (01)

[39] ApoE variant p.V236E is associated with markedly reduced risk of Alzheimer's disease [J].

Medway, Christopher W. ;

Abdul-Hay, Samer ;

Mims, Tynickwa ;

Ma, Li ;

Bisceglio, Gina ;

Zou, Fanggeng ;

Pankratz, Shane ;

Sando, Sigrid B. ;

Aasly, Jan O. ;

Barcikowska, Maria ;

Siuda, Joanna ;

Wszolek, Zbigniew K. ;

Ross, Owen A. ;

Carrasquillo, Minerva ;

Dickson, Dennis W. ;

Graff-Radford, Neill ;

Petersen, Ronald C. ;

Ertekin-Taner, Niluefer ;

Morgan, Kevin ;

Bu, Guojun ;

Younkin, Steven G. .

MOLECULAR NEURODEGENERATION, 2014, 9

[40] REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer's Disease [J].

Meyer, Katharina ;

Feldman, Heather M. ;

Lu, Tao ;

Drake, Derek ;

Lim, Elaine T. ;

Ling, King-Hwa ;

Bishop, Nicholas A. ;

Pan, Ying ;

Seo, Jinsoo ;

Lin, Yuan-Ta ;

Su, Susan C. ;

Church, George M. ;

Tsai, Li-Huei ;

Yankner, Bruce A. .

CELL REPORTS, 2019, 26 (05) :1112-+

← 1 2 3 4 5 6 7 8 →