Esculeoside A Decreases Diabetic Cardiomyopathy in Streptozotocin-Treated Rats by Attenuating Oxidative Stress, Inflammation, Fibrosis, and Apoptosis: Impressive Role of Nrf2

被引:6
作者
Altamimi, Jozaa Z. [1 ]
Alfaris, Nora A. [1 ]
Alshammari, Ghedeir M. [2 ]
Alagal, Reham I. [3 ]
Aljabryn, Dalal H. [1 ]
Yahya, Mohammed Abdo [2 ]
机构
[1] Princess Nourah Bint Abdulrahman Univ, Coll Educ, Dept Phys Sports Sci, Riyadh 11671, Saudi Arabia
[2] King Saud Univ, Coll Food & Agr Sci, Dept Food Sci & Nutr, Riyadh 11451, Saudi Arabia
[3] Princess Nourah Bint Abdulrahman Univ, Coll Hlth & Rehabil Sci, Dept Hlth Sci, Riyadh 11671, Saudi Arabia
来源
MEDICINA-LITHUANIA | 2023年 / 59卷 / 10期
关键词
Esculeoside A; diabetic; cardiomyopathy; oxidative stress; inflammation; Nrf2; APOE-DEFICIENT MICE; AMELIORATES HYPERLIPIDEMIA; TOMATO SAPOGENOL; IN-VITRO; ATHEROSCLEROSIS; ACTIVATION; EXPRESSION; PLANTS; DAMAGE;
D O I
10.3390/medicina59101830
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background and Objectives: This experiment evaluated the preventative influence of the tomato-derived Esculeoside A (ESA) on diabetic cardiomyopathy in type 1 diabetes mellitus (T1DM) in rats induced by streptozotocin (STZ). It also examined whether the activation of Nrf2 signaling affords this protection. Materials and Methods: Adult male Wistar control nondiabetic rats and rats with T1DM (STZ-T1DM) were given either carboxymethylcellulose as a vehicle or ESA (100 mg/kg) (eight rats/group) orally daily for 12 weeks. A group of STZ-T1DM rats was also treated with 100 mg/kg ESA and co-treated i.p. with 2 mg/kg (twice/week), brusatol, and Nrf2 inhibitors for 12 weeks. Results and Conclusions: Treatment with ESA prevented the gain in heart weight and cardiomyocyte hypertrophy and improved the left ventricular (LV) systolic and diastolic function (LV) in the STZ-T1DM rat group. Likewise, it reduced their serum levels of triglycerides, cholesterol, and low-density lipoproteins (LDL-c), as well as their LV mRNA, cytoplasmic total, and nuclear total levels of NF-kappa B. ESA also reduced the total levels of malondialdehyde, tumor necrosis factor-alpha, interleukine-6 (IL-6), Bax, cytochrome-c, and caspase-3 in the LV of the STZ-T1DM rats. In parallel, ESA enhanced the nuclear and cytoplasmic levels of Nrf2 and the levels of superoxide dismutase, glutathione, and heme oxygenase-1, but decreased the mRNA and cytoplasmic levels of keap-1 in the LVs of the STZ-T1DM rats. Interestingly, ESA did not affect the fasting insulin and glucose levels of the diabetic rats. All of these beneficially protective effects of ESA were not seen in the ESA-treated rats that received brusatol. In conclusion, ESA represses diabetic cardiomyopathy in STZ-diabetic hearts by activating the Nrf2/antioxidant/NF-kappa B axis.
引用
收藏
页数:18
相关论文
共 69 条
  • [41] Signaling Pathways Related to Oxidative Stress in Diabetic Cardiomyopathy
    Peng, Meng-ling
    Fu, Yu
    Wu, Chu-wen
    Zhang, Ying
    Ren, Hang
    Zhou, Shan-shan
    [J]. FRONTIERS IN ENDOCRINOLOGY, 2022, 13
  • [42] Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis
    Pinton, P.
    Giorgi, C.
    Siviero, R.
    Zecchini, E.
    Rizzuto, R.
    [J]. ONCOGENE, 2008, 27 (50) : 6407 - 6418
  • [43] Sinapic acid ameliorates cardiac dysfunction and cardiomyopathy by modulating NF-κB and Nrf2/HO-1 signaling pathways in streptozocin induced diabetic rats
    Raish, Mohammad
    Ahmad, Ajaz
    Bin Jardan, Yousef A.
    Shahid, Mudassar
    Alkharfy, Khalid M.
    Ahad, Abdul
    Ansari, Mushtaq Ahmad
    Abdelrahman, Ibrahim Abdelsalam
    Al-Jenoobi, Fahad, I
    [J]. BIOMEDICINE & PHARMACOTHERAPY, 2022, 145
  • [44] Cannabidiol Attenuates Cardiac Dysfunction, Oxidative Stress, Fibrosis, and Inflammatory and Cell Death Signaling Pathways in Diabetic Cardiomyopathy
    Rajesh, Mohanraj
    Mukhopadhyay, Partha
    Batkai, Sandor
    Patel, Vivek
    Saito, Keita
    Matsumoto, Shingo
    Kashiwaya, Yoshihiro
    Horvath, Bela
    Mukhopadhyay, Bani
    Becker, Lauren
    Hasko, Gyoergy
    Liaudet, Lucas
    Wink, David A.
    Veves, Aristidis
    Mechoulam, Raphael
    Pacher, Pal
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2010, 56 (25) : 2115 - 2125
  • [45] Effects of Capparis Spinosa extract on the neuropathic pain induced by chronic constriction injury in rats
    Rakhshandeh, Hassan
    Pourbagher-Shahri, Ali Mohammad
    Hasanpour, Maede
    Iranshahi, Mehrdad
    Forouzanfar, Fatemeh
    [J]. METABOLIC BRAIN DISEASE, 2022, 37 (08) : 2839 - 2852
  • [46] Type 1 Diabetes Mellitus in Saudi Arabia: A Soaring Epidemic
    Robert, Asirvatham Alwin
    Al-Dawish, Abdulrahman
    Mujammami, Muhammad
    Al Dawish, Mohamed Abdulaziz
    [J]. INTERNATIONAL JOURNAL OF PEDIATRICS, 2018, 2018
  • [47] Inhibitory Role of the KEAP1-NRF2 Pathway in TGFβ1-Stimulated Renal Epithelial Transition to Fibroblastic Cells: A Modulatory Effect on SMAD Signaling
    Ryoo, In-geun
    Ha, Hunjoo
    Kwak, Mi-Kyoung
    [J]. PLOS ONE, 2014, 9 (04):
  • [48] Diabetic Cardiomyopathy Bench to Bedside
    Schilling, Joel D.
    Mann, Douglas L.
    [J]. HEART FAILURE CLINICS, 2012, 8 (04) : 619 - +
  • [49] Oxidative Stress in Cardiovascular Diseases: Still a Therapeutic Target?
    Senoner, Thomas
    Dichtl, Wolfgang
    [J]. NUTRIENTS, 2019, 11 (09)
  • [50] Protective effects of medicinal plant against diabetes induced cardiac disorder: A review
    Shabab, Sadegh
    Gholamnezhad, Zahra
    Mahmoudabady, Maryam
    [J]. JOURNAL OF ETHNOPHARMACOLOGY, 2021, 265