miRNAs orchestration of cardiovascular diseases-Particular emphasis on diagnosis, and progression

被引：28

作者：

Elsakka, Elsayed G. E. ^{[1
]}

Abulsoud, Ahmed I. ^{[1
,2
]}

El-Mahdy, Hesham A. ^{[1
]}

Ismail, Ahmed ^{[1
]}

Elballal, Mohammed S. ^{[3
]}

Mageed, Sherif S. Abdel ^{[4
]}

Khidr, Emad Gamil ^{[1
]}

Mohammed, Osama A. ^{[5
,6
]}

Sarhan, Omnia M. ^{[7
]}

Elkhawaga, Samy Y. ^{[1
]}

El-Husseiny, Ahmed A. ^{[1
,8
]}

Abdelmaksoud, Nourhan M. ^{[2
]}

El-Demerdash, Aya A. ^{[4
]}

Shahin, Reem K. ^{[3
]}

Midan, Heba M. ^{[3
]}

Elrebehy, Mahmoud A. ^{[3
]}

Doghish, Ayman A. ^{[9
]}

Doghish, Ahmed S. ^{[3
,10
]}

机构：

[1] Al Azhar Univ, Fac Pharm Boys, Biochem & Mol Biol Dept, Cairo 11231, Egypt

[2] Heliopolis Univ, Fac Pharm, Biochem Dept, Cairo 11785, Egypt

[3] Badr Univ Cairo BUC, Fac Pharm, Dept Biochem, Cairo 11829, Egypt

[4] Badr Univ Cairo BUC, Fac Pharm, Pharmacol & Toxicol Dept, Cairo 11829, Egypt

[5] Bisha Univ, Fac Med, Dept Clin Pharmacol, Bisha 61922, Saudi Arabia

[6] Ain Shams Univ, Fac Med, Dept Clin Pharmacol, Cairo 11566, Egypt

[7] Badr Univ Cairo BUC, Fac Pharm, Dept Pharmaceut & Ind Pharm, Cairo 11829, Egypt

[8] Egyptian Russian Univ, Fac Pharm, Dept Biochem, Cairo 11829, Egypt

[9] Ain Shams Univ Hosp, Fac Med, Dept Cardiovasc & Thorac Surg, Cairo, Egypt

[10] Al Azhar Univ, Fac Pharm Boys, Cairo 11231, Egypt

来源：

PATHOLOGY RESEARCH AND PRACTICE | 2023年 / 248卷

关键词：

MiRNA; Cardiovascular diseases; Diagnosis; Prognosis; Transcriptional regulation; Epigenetic regulation; MYOCARDIAL ISCHEMIA/REPERFUSION INJURY; PULMONARY ARTERIAL-HYPERTENSION; ISCHEMIA-REPERFUSION INJURY; PROMOTES CARDIAC FIBROSIS; HYPOXIA-INDUCED APOPTOSIS; HEART-FAILURE; CIRCULATING MICRORNAS; CELL-DEATH; PROTECTS CARDIOMYOCYTES; ATRIAL-FIBRILLATION;

D O I：

10.1016/j.prp.2023.154613

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

MicroRNAs (miRNAs; miRs) are small non-coding ribonucleic acids sequences vital in regulating gene expression. They are significant in many biological and pathological processes and are even detectable in various body fluids such as serum, plasma, and urine. Research has demonstrated that the irregularity of miRNA in multiplying cardiac cells is linked to developmental deformities in the heart's structure. It has also shown that miRNAs are crucial in diagnosing and progressing several cardiovascular diseases (CVDs). The review covers the function of miRNAs in the pathophysiology of CVD. Additionally, the review provides an overview of the potential role of miRNAs as disease-specific diagnostic and prognostic biomarkers for human CVD, as well as their biological implications in CVD.

引用

页数：17

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