Epidemiology and Geographic Distribution of Generalized Pustular Psoriasis in Spain: A National Population-Based Study of Hospital Admissions from 2016 to 2020

Introduction: Little has been published on the epidemiology of generalized pustular psoriasis( GPP). The aim of this study was to describe and analyze the geographic distribution of hospitaladmissions for GPP in Spain. Methods: We performed a cross-sectional study using the hospital discharge database of theSpanish Basic Minimum Data Set (CMBD), which is a mandatory data set of all admissions topublic hospitals in the country. We included patients with a primary diagnosis of psoriasis orGPP at discharge for the period 2016 to 2020. We performed a descriptive analysis of clinicaland sociodemographic characteristics of patients admitted with GPP, a spatial analysis at theprovince level assessing the presence of geographic heterogeneity and a GPP disease map. Results: We detected 949 diagnoses of psoriasis and 744 primary diagnoses of GPP. Mean ageof patients admitted with GPP was 62.2 years. Intensive care unit admissions were ordered for 6.1% of patients and 4.8% died. The overall incidence rate of GPP among newly hospitalizedpatients during the study period was 3.18 cases per 1,000,000 person-years. The geographicdistribution varied widely, with higher rates observed in the north-west of the country. Conclusions: We describe the characteristics of GPP hospitalized patients in Spain and providethe first disease map for the country. The findings could help guide future research and suggestthe possibility of genetic or environmental factors driving geographic differences. (c) 2022 AEDV. Published by Elsevier Espana, S.L.U. This is an open access article under the CCBYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).