An Overview of Aplysinopsins: Synthesis and Biological Activities

被引：3

作者：

El-Sawy, Eslam R. ^{[1
]}

Kirsch, Gilbert ^{[2
]}

机构：

[1] Natl Res Ctr, Chem Nat Cpds Dept, Giza 12622, Egypt

[2] Univ Lorraine, Lab Lorrain Cim Mol L2CM, F-57050 Metz, France

来源：

MARINE DRUGS | 2023年 / 21卷 / 05期

关键词：

aplysinopsin; sources; synthesis; analogs; bioactivity; MARINE NATURAL-PRODUCTS; FAMILY DENDROPHYLLIIDAE; SCLERACTINIAN CORALS; STONY CORAL; ALKALOIDS; METABOLITES; SPONGES; DERIVATIVES; INDOLE; INHIBITOR;

D O I：

10.3390/md21050268

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Marine products are among the most promising sources of biologically active molecules. Aplysinopsins, tryptophan-derived marine natural products, were isolated from different natural marine sources including sponges, stony corals (hard corals) especially genus scleractinian, as well as sea anemone, in addition to one nudibranch. Aplysinopsins were reported to be isolated from different marine organisms related to various geographic areas such as Pacific, Indonesia, Caribbean, and Mediterranean regions. This review gives an up-to-date overview of marine alkaloid aplysinopsins: their various sources, their synthesis, and the fact that many aplysinopsin derivatives are biologically active compounds.

引用

页数：15

共 50 条

[1] Tryptophan derived natural marine alkaloids and synthetic derivatives as promising antimicrobial agents [J].

Almeida, Mariana C. ;

Resende, Diana I. S. P. ;

da Costa, Paulo M. ;

Pinto, Madalena M. M. ;

Sousa, Emilia .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 209

[2]

[Anonymous], 2018, ANGEW CHEM, DOI [10.1002/ange.201806357, DOI 10.1002/ANGE.201806357]

[3] Novel neuronal nitric oxide synthase (nNOS) selective inhibitor, aplysinopsin-type indole alkaloid, from marine sponge Hyrtios erecta [J].

Aoki, S ;

Ye, Y ;

Higuchi, K ;

Takashima, A ;

Tanaka, Y ;

Kitagawa, I ;

Kobayashi, M .

CHEMICAL & PHARMACEUTICAL BULLETIN, 2001, 49 (10) :1372-1374

[4] METHYLAPLYSINOPSIN - A NATURAL PRODUCT OF MARINE ORIGIN WITH EFFECTS ON SEROTONERGIC NEUROTRANSMISSION [J].

BAIRDLAMBERT, J ;

DAVIS, PA ;

TAYLOR, KM .

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 1982, 9 (02) :203-212

[5] Australian marine sponge alkaloids as a new class of glycine-gated chloride channel receptor modulator [J].

Balansa, Walter ;

Islam, Robiul ;

Gilbert, Daniel F. ;

Fontaine, Frank ;

Xiao, Xue ;

Zhang, Hua ;

Piggott, Andrew M. ;

Lynch, Joseph W. ;

Capon, Robert J. .

BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 21 (14) :4420-4425

[6] Aplysinopsins - Marine Indole Alkaloids: Chemistry, Bioactivity and Ecological Significance [J].

Bialonska, Dobroslawa ;

Zjawiony, Jordan K. .

MARINE DRUGS, 2009, 7 (02) :166-183

[7] New Antimalarial and Antimicrobial Tryptamine Derivatives from the Marine Sponge Fascaplysinopsis reticulata [J].

Campos, Pierre-Eric ;

Pichon, Emmanuel ;

Moriou, Celine ;

Clerc, Patricia ;

Trepos, Rozenn ;

Frederich, Michel ;

De Voogd, Nicole ;

Hellio, Claire ;

Gauvin-Bialecki, Anne ;

Al-Mourabit, Ali .

MARINE DRUGS, 2019, 17 (03)

[8] Synthesis and structure-affinity relationships of novel small molecule natural product derivatives capable of discriminating between serotonin 5-HT1A, 5-HT2A, 5-HT2C receptor subtypes [J].

Cummings, David F. ;

Canseco, Diana C. ;

Sheth, Pratikkumar ;

Johnson, James E. ;

Schetz, John A. .

BIOORGANIC & MEDICINAL CHEMISTRY, 2010, 18 (13) :4783-4792

[9] Dictazolines A and B, bisspiroimidazolidinones from the marine sponge Smenospongia cerebriformis [J].

Dai, Jingqiu ;

Jimenez, Jorge I. ;

Kelly, Michelle ;

Barnes, Shawn ;

Lorenzo, Patricia ;

Williams, Philip .

JOURNAL OF NATURAL PRODUCTS, 2008, 71 (07) :1287-1290

[10] Dictazoles: Potential Vinyl Cyclobutane Biosynthetic Precursors to the Dictazolines [J].

Dai, Jingqiu ;

Jimenez, Jorge I. ;

Kelly, Michelle ;

Williams, Philip G. .

JOURNAL OF ORGANIC CHEMISTRY, 2010, 75 (07) :2399-2402

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