Vegetal-Derived Bioactive Compounds as Multidrug Resistance Modulators in Colorectal Cancer

被引：11

作者：

Quinonero, Francisco ^{[1
,2
,3
]}

Mesas, Cristina ^{[1
,2
,3
]}

Pena, Mercedes ^{[1
,2
,3
]}

Cabeza, Laura ^{[1
,2
,3
]}

Perazzoli, Gloria ^{[1
,2
,3
]}

Melguizo, Consolacion ^{[1
,2
,3
]}

Ortiz, Raul ^{[1
,2
,3
]}

Prados, Jose ^{[1
,2
,3
]}

机构：

[1] Univ Granada, Inst Biopathol & Regenerat Med IBIMER, Ctr Biomed Res CIBM, Granada 18100, Spain

[2] Univ Granada, Fac Med, Dept Anat & Embryol, Granada 18071, Spain

[3] Inst Invest Biosanit Granada ibs GRANADA, Granada 18014, Spain

来源：

APPLIED SCIENCES-BASEL | 2023年 / 13卷 / 04期

关键词：

colorectal cancer; vegetables; multidrug resistance; biomolecules; resistance mechanisms; PLANT ESSENTIAL OILS; COLON-CANCER; DRUG-RESISTANCE; CELL-PROLIFERATION; GROWTH-FACTOR; IN-VITRO; RESVERATROL; CURCUMIN; 5-FLUOROURACIL; APOPTOSIS;

D O I：

10.3390/app13042667

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Colorectal cancer is one of the leading causes of morbidity and mortality today. Knowledge of its pathogenesis has made it possible to advance the development of different therapeutic strategies. However, the appearance of drug resistance constitutes one of the main causes of treatment failure. Bioactive compounds of vegetable origin are being studied as a new strategy to improve antitumor treatment, due to their ability to regulate the pathways involved in the development of carcinogenesis or processes that are decisive in its evolution, including multidrug resistance. In vitro and in vivo studies of these substances in combination with cytotoxic drugs have shown that they reduce resistance and increase therapeutic efficacy. The objective of this review is to summarize the knowledge that is described in the scientific literature on the antitumor and chemo-sensitizing capacity of vegetable-derived biomolecules such as polyphenols, flavonoids, and terpenes. These compounds may hold a promising future in improving the treatment of colorectal cancer.

引用

页数：20

共 135 条

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