Nickel-Catalyzed Reductive Cross-Coupling of Aziridines and Allylic Chlorides

被引：10

作者：

Liu, Shuai ^{[1
]}

Wang, Sen-Lin ^{[1
]}

Wan, Jie ^{[1
]}

Peng, Shuang ^{[1
]}

Zhang, Jie-Rui ^{[1
]}

Ding, Hua-Jiao ^{[1
]}

Zhang, Bin ^{[1
]}

Ni, Hai-Liang ^{[1
]}

Cao, Peng ^{[1
]}

Hu, Ping ^{[1
]}

Wang, Bi-Qin ^{[1
]}

Chen, Bin ^{[1
]}

机构：

[1] Sichuan Normal Univ, Coll Chem & Mat Sci, Chengdu 610068, Peoples R China

来源：

ORGANIC LETTERS | 2023年 / 25卷 / 35期

关键词：

ALLYLATION; HALIDES; 2-ARYLAZIRIDINES; AMINOFLUORINATION; SUBSTITUTION; ALKENES; ACID;

D O I：

10.1021/acs.orglett.3c02399

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A nickel-catalyzed reductive cross-coupling of aziridines and allylic chlorides was realized by using manganese metal as the reducing agent. This protocol afforded a convenient approach to obtain beta-allyl-substituted arylethylamines bearing various functional groups. The utility of this reaction was also demonstrated by scale-up preparation and diverse transformations, including the synthesis of Baclofen and several bioactive molecular motifs.

引用

页码：6582 / 6586

页数：5

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