Omicron Infections in Vaccinated Pediatric Solid Organ Transplant Recipients

被引：0

作者：

McAteer, John ^{[1
,2
,14
]}

Kalluri, Divya D. ^{[3
]}

Abedon, Rivka R. ^{[3
]}

Qin, Caroline X. ^{[2
,3
]}

Auerbach, Scott R. ^{[4
]}

Charnaya, Olga ^{[2
]}

Danziger-Isakov, Lara A. ^{[5
]}

Ebel, Noelle H. ^{[6
]}

Feldman, Amy G. ^{[7
]}

Hsu, Evelyn K. ^{[8
]}

Mohammad, Saeed ^{[9
]}

Perito, Emily R. ^{[10
]}

Thomas, Ashley M. ^{[11
]}

Chiang, Teresa P. Y. ^{[3
]}

Garonzik-Wang, Jacqueline M. ^{[12
]}

Segev, Dorry L. ^{[13
]}

Werbel, William A. ^{[3
]}

Mogul, Douglas B. ^{[11
]}

机构：

[1] Johns Hopkins Univ, Johns Hopkins Childrens Ctr, Sch Med, Div Infect Dis,Dept Pediat, Baltimore, MD USA

[2] Johns Hopkins Univ, Sch Med, Johns Hopkins Childrens Ctr, Div Nephrol,Dept Pediat, Baltimore, MD USA

[3] Johns Hopkins Univ, Sch Med, Johns Hopkins Hosp, Dept Surg, Baltimore, MD USA

[4] Univ Colorado, Childrens Hosp Colorado, Dept Pediat, Div Cardiol, Anschutz Med Campus, Aurora, CO USA

[5] Univ Cincinnati, Cincinnati Childrens Hosp Med Ctr, Dept Pediat, Div Infect Dis, Cincinnati, OH USA

[6] Stanford Univ, Sch Med, Lucile Packard Childrens Hosp Stanford, Div Gastroenterol Hepatol & Nutr,Dept Pediat, Palo Alto, CA USA

[7] Univ Colorado Denver, Childrens Hosp Colorado, Digest Hlth Inst, Sect Gastroenterol Hepatol & Nutr,Sch Med, Aurora, CO USA

[8] Univ Washington, Seattle Childrens Hosp, Sch Med, Div Gastroenterol Hepatol & Nutr,Dept Pediat, Seattle, WA USA

[9] Vanderbilt Univ, Med Ctr, Dept Pediat, Div Gastroenterol Hepatol & Nutr, Nashville, TN USA

[10] Univ Calif San Francisco, Benioff Childrens Hosp, Dept Pediat, Div Gastroenterol Hepatol & Nutr, San Francisco, CA USA

[11] Johns Hopkins Univ, Sch Med, Johns Hopkins Childrens Ctr, Dept Pediat,Sect Gastroenterol Hepatol & Nutr, Baltimore, MD USA

[12] NYU, Grossman Sch Med, New York, NY USA

[13] Univ Wisconsin, Sch Med & Publ Hlth, Dept Surg, Div Transplant Surg, Milwaukee, WI USA

[14] Johns Hopkins Sch Med, Dept Pediat, 600 N Wolfe St, Baltimore, MD 21287 USA

来源：

JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY | 2024年 / 13卷 / 02期

基金：

美国国家卫生研究院;

关键词：

breakthrough; COVID-19; mRNA vaccination; Omicron variant; pediatrics; solid organ transplant;

D O I：

10.1093/jpids/piad108

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

SARS-CoV-2 infection during the Omicron period was frequent amongst a cohort of vaccinated pediatric solid organ transplant recipients (pSOTRs) despite robust anti-receptor-binding domain (anti-RBD) antibody response, suggesting poor neutralizing capacity against Omicron subvariants. Breakthrough infections among pSOTRs were overall limited in severity.

引用

页码：152 / 154

页数：3

共 8 条

[1] Omicron variant susceptibility to neutralizing antibodies induced in children by natural SARS-CoV-2 infection or COVID-19 vaccine [J].

Chen, Lin-Lei ;

Chua, Gilbert T. ;

Lu, Lu ;

Chan, Brian Pui-Chun ;

Wong, Joshua Sung-Chih ;

Chow, Calvin Chit-Kwong ;

Yu, Tak-Ching ;

Leung, Agnes Sze-Yin ;

Lam, Shu-Yan ;

Wong, Tak-Wai ;

Tsang, Hing-Wai ;

Wong, Ian Chi-Kei ;

Chan, Kwok-Hung ;

Yuen, Kwok-Yung ;

Ip, Patrick ;

Kwan, Mike Yat-Wah ;

To, Kelvin Kai-Wang .

EMERGING MICROBES & INFECTIONS, 2022, 11 (01) :543-547

[2] COVID-19 Clinical Outcomes in Solid Organ Transplant Recipients During the Omicron Surge [J].

Cochran, Willa ;

Shah, Pali ;

Barker, Lindsay ;

Langlee, Julie ;

Freed, Kristin ;

Boyer, Lauren ;

Scott Anderson, R. ;

Belden, Maura ;

Bannon, Jaclyn ;

Kates, Olivia S. ;

Permpalung, Nitipong ;

Mostafa, Heba ;

Segev, Dorry L. ;

Brennan, Daniel C. ;

Avery, Robin K. .

TRANSPLANTATION, 2022, 106 (07) :E346-E347

[3]

Karaba AH, 2022, AM J TRANSPLANT, V22, P1253, DOI [10.1111/ajt.16933, 10.1101/2021.08.11.21261914]

[4]

Patel Eshan U, 2020, medRxiv, DOI [10.1128/JCM.02257-20, 10.1101/2020.08.31.20184788]

[5] Understanding Kids and COVID [J].

Peeples, Lynne .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2022, 119 (13)

[6]

Roche Diagnostics, Elecsys anti-SARS-CoV-2 package insert 2020-07, v3.0

[7]

materialnumbers 09203095190 and 09203079190

[8] Correlation Analysis of Anti-SARS-CoV-2 RBD IgG and Neutralizing Antibody against SARS-CoV-2 Omicron Variants after Vaccination [J].

Takheaw, Nuchjira ;

Liwsrisakun, Chalerm ;

Chaiwong, Warawut ;

Laopajon, Witida ;

Pata, Supansa ;

Inchai, Juthamas ;

Duangjit, Pilaiporn ;

Pothirat, Chaicharn ;

Bumroongkit, Chaiwat ;

Deesomchok, Athavudh ;

Theerakittikul, Theerakorn ;

Limsukon, Atikun ;

Tajarernmuang, Pattraporn ;

Niyatiwatchanchai, Nutchanok ;

Trongtrakul, Konlawij ;

Kasinrerk, Watchara .

DIAGNOSTICS, 2022, 12 (06)

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