Activated Tryptophan-Kynurenine metabolic system in the human brain is associated with learned fear

被引：40
作者：
Battaglia, Maria Rita [1 ]
Di Fazio, Chiara [2 ]
Battaglia, Simone [2 ,3 ]
机构：
[1] Ist Ricovero & Cura Carattere Sci Azienda Osp Univ, Policlin S Orsola, Bologna, Italy
[2] Univ Bologna, Ctr Studies & Res Cognit Neurosci, Dept Psychol, Bologna, Italy
[3] Univ Turin, Dept Psychol, Turin, Italy
来源：
FRONTIERS IN MOLECULAR NEUROSCIENCE | 2023年 / 16卷
关键词：
Tryptophan-Kynurenine pathway; learned fear; fear conditioning; PFC-dependent cognition; neuropsychiatric disorders; KYN pathway; prefrontal cortex (PFC); VENTROMEDIAL PREFRONTAL CORTEX; CEREBROSPINAL-FLUID; INDIVIDUAL-DIFFERENCES; ACID LEVELS; EXTINCTION; PATHWAY; SCHIZOPHRENIA; ACQUISITION; INHIBITION; INCREASES;
D O I：
10.3389/fnmol.2023.1217090
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
[No abstract available]
引用
收藏
页数：8
相关论文
共 116 条
[1]   Exposure to Kynurenic Acid During Adolescence Produces Memory Deficits in Adulthood [J].
Akagbosu, Cynthia O. ;
Evans, Gretchen C. ;
Gulick, Danielle ;
Suckow, Raymond F. ;
Bucci, David J. .
SCHIZOPHRENIA BULLETIN, 2012, 38 (04) :769-778
[2]   Acute elevations of brain kynurenic acid impair cognitive flexibility: Normalization by the alpha7 positive modulator galantamine [J].
Kathleen S. Alexander ;
Hui-Qiu Wu ;
Robert Schwarcz ;
John P. Bruno .
Psychopharmacology, 2012, 220 (3) :627-637
[3]   On the relationship between the two branches of the kynurenine pathway in the rat brain in vivo [J].
Amori, Laura ;
Guidetti, Paolo ;
Pellicciari, Roberto ;
Kajii, Yasushi ;
Schwarcz, Robert .
JOURNAL OF NEUROCHEMISTRY, 2009, 109 (02) :316-325
[4]   The Role of Kynurenine and Its Metabolites in Comorbid Chronic Pain and Depression [J].
Athnaiel, Onella ;
Ong, Charmaine ;
Knezevic, Nebojsa Nick .
METABOLITES, 2022, 12 (10)
[5]   Crosstalk between Existential Phenomenological Psychotherapy and Neurological Sciences in Mood and Anxiety Disorders [J].
Balogh, Lehel ;
Tanaka, Masaru ;
Torok, Nora ;
Vecsei, Laszlo ;
Taguchi, Shigeru .
BIOMEDICINES, 2021, 9 (04)
[6]   The kynurenine pathway in bipolar disorder: a meta-analysis on the peripheral blood levels of tryptophan and related metabolites [J].
Bartoli, Francesco ;
Misiak, Blazej ;
Callovini, Tommaso ;
Cavaleri, Daniele ;
Cioni, Riccardo M. ;
Crocamo, Cristina ;
Savitz, Jonathan B. ;
Carra, Giuseppe .
MOLECULAR PSYCHIATRY, 2021, 26 (07) :3419-3429
[7]   Fear-induced bradycardia in mental disorders: Foundations, current advances, future perspectives [J].
Battaglia, S. ;
Nazzi, C. ;
Thayer, J. F. .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2023, 149
[8]   Neuropharmacological Modulation of N-methyl-D-aspartate, Noradrenaline and Endocannabinoid Receptors in Fear Extinction Learning: Synaptic Transmission and Plasticity [J].
Battaglia, Simone ;
Di Fazio, Chiara ;
Vicario, Carmelo M. ;
Avenanti, Alessio .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (06)
[9]   Stopping in (e)motion: Reactive action inhibition when facing valence-independent emotional stimuli [J].
Battaglia, Simone ;
Cardellicchio, Pasquale ;
Di Fazio, Chiara ;
Nazzi, Claudio ;
Fracasso, Alessio ;
Borgomaneri, Sara .
FRONTIERS IN BEHAVIORAL NEUROSCIENCE, 2022, 16
[10]   The Influence of Vicarious Fear-Learning in "Infecting" Reactive Action Inhibition [J].
Battaglia, Simone ;
Cardellicchio, Pasquale ;
Di Fazio, Chiara ;
Nazzi, Claudio ;
Fracasso, Alessio ;
Borgomaneri, Sara .
FRONTIERS IN BEHAVIORAL NEUROSCIENCE, 2022, 16
12345678910