Real-World Evaluation of Anticoagulant Treatment Patterns in Patients with Atrial Fibrillation: Data from Multicenter ROTA Study

被引：3

作者：

Kocabas, Umut ^{[1
]}

Ergin, Isil ^{[2
]}

Yavuz, Veysel ^{[3
]}

Murat, Selda ^{[4
]}

Ozdemir, Ibrahim ^{[5
]}

Genc, Omer ^{[6
]}

Altin, Cihan ^{[7
]}

Tuner, Hasim ^{[8
]}

Meric, Bengisu Keskin ^{[9
]}

coner, Ali ^{[10
]}

Yuce, Elif Ilkay ^{[11
]}

Boyraz, Bedrettin ^{[12
]}

Aslan, Onur ^{[13
]}

Dal, Ahmet ^{[7
]}

Sen, Taner ^{[14
]}

Ibisoglu, Ersin ^{[15
]}

Erdogan, Aslan ^{[15
]}

Ozgeyik, Mehmet ^{[16
]}

Demir, Mevlut ^{[14
]}

Bilgel, Ziya Gokalp ^{[17
]}

Sengor, Busra Guvendi ^{[18
]}

Urgun, Orsan Deniz ^{[19
]}

Dogdus, Mustafa ^{[20
]}

Tekin, Deniz Dilan Naki ^{[15
]}

Cakal, Sinem ^{[21
]}

Cayirli, Sercan ^{[22
]}

Guler, Arda ^{[23
]}

Karabulut, Dilay ^{[24
]}

Dalgic, Onur ^{[25
]}

Uzman, Osman ^{[26
]}

Murat, Bektas ^{[16
]}

Sahin, Seyda ^{[27
]}

Karabulut, Umut ^{[28
]}

Kivrak, Tarik ^{[29
]}

Cosgun, Muharrem Said ^{[30
]}

Ozyurtlu, Ferhan ^{[31
]}

Kaplan, Mehmet ^{[32
]}

Ozcalik, Emre

机构：

[1] Baskent Univ, Dept Cardiol, Izmir Hosp, Izmir, Turkiye

[2] Ege Univ, Fac Med, Dept Publ Hlth, Izmir, Turkiye

[3] Akhisar State Hosp, Dept Cardiol, Manisa, Turkiye

[4] Eskisehir Osmangazi Univ, Fac Med, Dept Cardiol, Eskisehir, Turkiye

[5] Manisa City Hosp, Dept Cardiol, Manisa, Turkiye

[6] Agri Training & Res Hosp, Dept Cardiol, Agri, Turkiye

[7] Izmir Univ Econ, Fac Med, Dept Cardiol, Izmir, Turkiye

[8] Hakkari State Hosp, Dept Cardiol, Hakkari, Turkiye

[9] Babaeski State Hosp, Dept Cardiol, Kirklareli, Turkiye

[10] Baskent Univ, Dept Cardiol, Alanya Hosp, Antalya, Turkiye

[11] Fethiye State Hosp, Dept Cardiol, Mugla, Turkiye

[12] Tatvan State Hosp, Dept Cardiol, Bitlis, Turkiye

[13] Mersin City Hosp, Dept Cardiol, Mersin, Turkiye

[14] Kutahya Hlth Sci Univ, Fac Med, Dept Cardiol, Kutahya, Turkiye

[15] Basaksehir Cam & Sakura City Hosp, Dept Cardiol, Istanbul, Turkiye

[16] Eskisehir City Hosp, Dept Cardiol, Eskisehir, Turkiye

[17] Baskent Univ, Dept Cardiol, Adana Hosp, Adana, Turkiye

[18] Maltepe State Hosp, Dept Cardiol, Istanbul, Turkiye

[19] Kozan State Hosp, Dept Cardiol, Adana, Turkiye

[20] Usak Univ Training & Res Hosp, Dept Cardiol, Usak, Turkiye

[21] Hlth Sci Univ, Haseki Training & Res Hosp, Dept Cardiol, Istanbul, Turkiye

[22] Adnan Menderes Univ, Fac Med, Dept Cardiol, Aydin, Turkiye

[23] Istanbul Mehmet Akif Ersoy Thorac & Cardiovasc Su, Dept Cardiol, Istanbul, Turkiye

[24] Istanbul Bakirkoy Dr Sadi Konuk Training & Res Ho, Dept Cardiol, Istanbul, Turkiye

[25] Kardiya Med Ctr, Dept Cardiol, Izmir, Turkiye

[26] Sarikamis State Hosp, Dept Cardiol, Kars, Turkiye

[27] Turhal State Hosp, Dept Cardiol, Tokat, Turkiye

[28] Istanbul Acibadem Int Hosp, Dept Cardiol, Istanbul, Turkiye

[29] Elazig Firat Univ, Fac Med, Dept Cardiol, Elazig, Turkiye

[30] Erzincan Binali Yildirim Univ, Mengucek Gazi Training & Res Hosp, Dept Cardiol, Erzincan, Turkiye

[31] Grandmed Hosp, Dept Cardiol, Manisa, Turkiye

[32] Gaziantep Univ, Fac Med, Dept Cardiol, Gaziantep, Turkiye

来源：

TURK KARDIYOLOJI DERNEGI ARSIVI-ARCHIVES OF THE TURKISH SOCIETY OF CARDIOLOGY | 2023年 / 51卷 / 02期

关键词：

Atrial fibrillation; anticoagulation; direct oral anticoagulants; stroke; systemic embolism; ANTAGONIST ORAL ANTICOAGULANTS; STROKE PREVENTION; EUROPEAN-SOCIETY; WARFARIN; GUIDELINES; MANAGEMENT; OUTCOMES; ADHERENCE;

D O I：

10.5543/tkda.2022.98455

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: Oral anticoagulant therapy is the cornerstone of atrial fibrillation management to prevent stroke and systemic embolism. However, there is limited real-world information regarding stroke and systemic embolism prevention strategies in patients with atrial fibrillation. The aim of the ROTA study is to obtain the real-world data of anticoagulant treatment patterns in patients with atrial fibrillation. Materials and Methods: The ROTA study is a prospective, multicenter, and observational study that included 2597 patients with atrial fibrillation. The study population was recruited from 41 cardiology outpatient clinics between January 2021 and May 2021.Results: The median age of the study population was 72 years (range: 22-98 years) and 57.4% were female. The median CHA2DS2-VASc and HAS-BLED scores were 4 (range: 0-9) and 1 (range: 0-6), respectively. Vitamin K antagonists and direct oral anticoagulants were used in 15.9% and 79.4% of patients, respectively. The mean time in therapeutic range was 52.9% for patients receiving vitamin K antagonists, and 76% of those patients had an inadequate time in therapeutic range with <70%. The most common prescribed direct oral anticoagulants were rivaroxaban (38.1%), apixaban (25.5%), and edoxaban (11.2%). The rate of overuse of vitamin K antagonists and direct oral anticoagulants was high (76.1%) in patients with low stroke risk, and more than one-fourth of patients on direct oral anticoagulant therapy were receiving a reduced dose of direct oral anticoagulants. Among patients who were on direct oral anticoagulant treatment, patients with apixaban treatment were older, had higher CHA2DS2- VASc and HAS-BLED scores, and had lower creatinine clearance than the patients receiving other direct oral anticoagulants.Conclusions: The ROTA study provides important real-world information about anticoagulant treatment patterns in patients with atrial fibrillation.

引用

页码：88 / 96

页数：9

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