Serum creatinine/cystatin C ratio is a predictor of all-cause mortality for older adults over 80 years

被引:6
作者
Zhang, Li [1 ]
Jin, Jun [1 ]
Tu, You-Yi [1 ]
Zhao, Zhe [1 ]
Tao, Jun [1 ]
Zhang, Xiao-yan [1 ]
机构
[1] Shanghai Jiao Tong Univ, Shanghai Sixth Peoples Hosp, Sch Med, Dept Geriatr, 600,Yi Shan Rd, Shanghai 200233, Peoples R China
关键词
Sarcopenia; Aging; Mortality; Sarcopenia index; SARCOPENIA; MARKER;
D O I
10.1016/j.heliyon.2023.e14214
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Objective: Sarcopenia is a prevalent condition in the senior population and has been related to adverse outcomes. This study aimed to investigate the performance of the serum creatinine/ cystatin C ratio (Cr/CysC) in predicting all-cause mortality in elders over 80 years.Methods: A total of 486 older patients over 80 were enrolled in this study. Calf circumference (CC) and handgrip strength (HGS) were carried out for each patient. All the participants accepted serum creatinine and cystatin C test. The primary clinical outcome was all-cause mortality during an over-4-year follow-up.Results: During an over 4-year follow-up, 200 participants died. The non-survivors had a signif-icantly lower baseline Cr/CysC level than the survivors (62.6 +/- 13.1 vs. 71.4 +/- 14.5 P < 0.001). The lowest Cr/CysC quartile group (Q1) had a significantly higher mortality rate than their counterparts (Q1 vs. Q2-4, 62.8% vs. 33.2%, P < 0.001). The Cr/CysC level was positively correlated with CC (R2 = 0.17, P < 0.001) and HGS (R2 = 0.19, P < 0.001). Moreover, survival curve was significantly worse in the lowest Cr/CysC quartile (Log-rank test chi 2 = 21.09, P < 0.001). After adjustment for potential confounders, age (HR, 1.10; 95% CI, 1.06-1.14, P < 0.001), coronary heart disease (HR, 1.49; 95% CI, 1.01-2.21, P = 0.045), and lowest Cr/CysC (HR, 1.59; 95% CI, 1.12-2.24, P = 0.009) were independent factors of all-cause mortality during the over-4 -year follow-up.Conclusion: Cr/CysC, also known as Sarcopenia Index, could be used as a predictor of all-cause mortality in older adults over 80 years.
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页数:8
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