Abuse of Anabolic-Androgenic Steroids and Adverse Effects on Human Organ Health: A Review

被引:2
作者
Ayubi, Novadri [1 ]
Kusnanik, Nining Widyah [1 ]
Herawati, Lilik [2 ]
Komaini, Anton [3 ]
Mutohir, Toho Cholik [1 ]
Callixte, Cyuzuzo [4 ]
Aljunaid, Mohammed [5 ]
Nurhasan, Nurhasan [1 ]
Muhammad, Heryanto Nur [1 ]
Purwanto, Bambang [2 ]
Rifki, Muhamad Sazeli [3 ]
Putri, Dhea Regita Sastika [2 ]
Syafawi, Atika [6 ]
机构
[1] Univ Negeri Surabaya, Surabaya, Indonesia
[2] Univ Airlangga, Surabaya, Indonesia
[3] Univ Negeri Padang, Padang, Indonesia
[4] Kibogora Polytech Univ, Nyamasheke Dist, Rwanda
[5] Univ Taiz, Taizi, Yemen
[6] Univ Andalas, Padang, Indonesia
来源
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY | 2023年 / 13卷 / 03期
关键词
anabolic-androgenic steroids; sport; exercise; healthy lifestyle; organs; CHRONIC HEART-FAILURE; OXIDATIVE STRESS; TESTOSTERONE TREATMENT; SKELETAL-MUSCLE; SEX STEROIDS; LIVER; HYPERTROPHY; EXERCISE; RATS; HORMONES;
D O I
10.33263/BRIAC133.281
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
Anabolic-androgenic steroids (AAS) are large groups of molecules structurally and functionally similar to the male hormone testosterone. The use of AAS is well known and widespread worldwide due to its androgenic and anabolic properties that can increase muscle mass and strength to support athlete performance. The prevalence of AAS worldwide reaches an incidence of 5% and is generally used by men aged 18-35. AAS has many side effects on the body's organs and is a serious problem for public health and athletics. This review aims to highlight the abuse of AAS and its detrimental effects on the health of human organs. Oxidative stress and apoptosis are common mechanisms that cause organ damage due to AAS use. Chronic administration of high doses of AAS results in cardiac dysfunction and increases the risks of life-threatening arrhythmias and sudden death. In addition, several organs that have the potential to be damaged by the use of AAS include the liver, kidneys, brain, musculoskeletal system, and reproductive organs. In this regard, education intervention and knowledge sharing are the important factors that should be used to raise awareness about preventing AAS abuse.
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页数:11
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