Extracellular Vesicles as Next-Generation Biomarkers in Lung Cancer Patients: A Case Report on Adenocarcinoma and Squamous Cell Carcinoma

被引：4

作者：

Ruzycka-Ayoush, Monika ^{[1
]}

Prochorec-Sobieszek, Monika ^{[2
]}

Cieszanowski, Andrzej ^{[3
]}

Glogowski, Maciej ^{[4
]}

Szumera-Cieckiewicz, Anna ^{[2
]}

Podgorska, Joanna ^{[3
]}

Targonska, Alicja ^{[5
]}

Sobczak, Kamil ^{[6
]}

Mosieniak, Grazyna ^{[5
]}

Grudzinski, Ireneusz P. ^{[1
]}

机构：

[1] Med Univ Warsaw, Fac Pharm, Banacha 1, PL-02097 Warsaw, Poland

[2] Maria Sklodowska Curie Natl Res Inst Oncol, Dept Canc Pathomorphol, Roentgena Str 5, PL-02781 Warsaw, Poland

[3] Maria Sklodowska Curie Natl Res Inst Oncol, Dept Clin Radiol, Roentgena Str 5, PL-02781 Warsaw, Poland

[4] Maria Sklodowska Curie Natl Res Inst Oncol, Dept Lung Canc & Chest Tumors, Roentgena Str 5, PL-02781 Warsaw, Poland

[5] Polish Acad Sci, Nencki Inst Expt Biol, Lab Mol Bases Ageing, PL-02093 Warsaw, Poland

[6] Univ Warsaw, Fac Chem, Biol & Chem Res Ctr, Zwirki i Wigury 101, PL-02089 Warsaw, Poland

来源：

LIFE-BASEL | 2024年 / 14卷 / 03期

关键词：

lung cancer; extracellular vesicles; surface proteins; biomarkers; diagnosis; EXPRESSION;

D O I：

10.3390/life14030408

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Extracellular vesicles (EVs) released from primary cell lines, originating from resected tissues during biopsies in patients with non-small cell lung cancer (NSCLC) revealing adenocarcinoma and squamous cell carcinoma subtypes, were examined for membrane proteomic fingerprints using a proximity barcoding assay. All the collected EVs expressed canonical tetraspanins (CD9, CD63, and CD81) highly coexpressed with molecules such as lysosome-associated membrane protein-1 (LAMP1-CD107a), sialomucin core protein 24 (CD164), Raph blood group (CD151), and integrins (ITGB1 and ITGA2). This representation of the protein molecules on the EV surface may provide valuable information on NSCLC subtypes and offer new diagnostic opportunities as next-generation biomarkers in personalized oncology.

引用

页数：9

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