Cytotoxicity and Anti-Angiogenic Potential of a Macro Alga, Ulva rigida C. Agardh (Green Alga) from Izmir Bay (Turkey)

被引：0

作者：

Guler, Cem

Guner, Adem

机构：

[1] Department of Biology, Faculty of Science, Ege University, Bornova-Izmir

[2] Department of Occupational Health and Safety, Faculty of Health Sciences, Sinop University, Sinop

来源：

BIOLOGY BULLETIN | 2023年 / 50卷 / SUPPL 3期

关键词：

Ulva rigida; green algae; macro algae; anticancer; anti-angiogenesis;

D O I：

10.1134/S1062359022603299

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Marine based organisms and their bioactive compounds are very attractive in terms of biomedical area. Due to marine ecosystem have harsh environment conditions; marine algae synthesize various bioactive compounds to survive. Genus Ulva (green macro algae) or sea lettuce species are the most abundant representatives abound in coastal waters and have various bioactive compounds. Therefore, Ulva sp. is extensively researched in especially cancer treatment. In this study, the ethanol extract of Ulva rigida C. Agardh collected from Izmir Bay was investigated by MTT, LDH, TAC, TOS and HET-CAM assays to determine its anticancer potential. The extract of U. rigida showed significant cytotoxic effect on human cervix adenocarcinoma (HeLa) cells (IC50 value is 21 +/- 4.84 mg/L). The extract had a moderate anti-angiogenic activity (Score value is 0.98 +/- 0.3 at 50 mu M concentration). Our results showed that U. rigida has a good potential cervical cancer therapy agent.

引用

页码：S261 / S269

页数：9

共 34 条

[31] Tumor Angiogenesis and Anti-Angiogenic Strategies for Cancer Treatment [J].