Cytotoxicity and Anti-Angiogenic Potential of a Macro Alga, Ulva rigida C. Agardh (Green Alga) from Izmir Bay (Turkey)

被引：0
作者：
Guler, Cem
Guner, Adem
机构：
[1] Department of Biology, Faculty of Science, Ege University, Bornova-Izmir
[2] Department of Occupational Health and Safety, Faculty of Health Sciences, Sinop University, Sinop
来源：
BIOLOGY BULLETIN | 2023年 / 50卷 / SUPPL 3期
关键词：
Ulva rigida; green algae; macro algae; anticancer; anti-angiogenesis;
D O I：
10.1134/S1062359022603299
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Marine based organisms and their bioactive compounds are very attractive in terms of biomedical area. Due to marine ecosystem have harsh environment conditions; marine algae synthesize various bioactive compounds to survive. Genus Ulva (green macro algae) or sea lettuce species are the most abundant representatives abound in coastal waters and have various bioactive compounds. Therefore, Ulva sp. is extensively researched in especially cancer treatment. In this study, the ethanol extract of Ulva rigida C. Agardh collected from Izmir Bay was investigated by MTT, LDH, TAC, TOS and HET-CAM assays to determine its anticancer potential. The extract of U. rigida showed significant cytotoxic effect on human cervix adenocarcinoma (HeLa) cells (IC50 value is 21 +/- 4.84 mg/L). The extract had a moderate anti-angiogenic activity (Score value is 0.98 +/- 0.3 at 50 mu M concentration). Our results showed that U. rigida has a good potential cervical cancer therapy agent.
引用
收藏
页码：S261 / S269
页数：9
相关论文
共 34 条
[1]  
Abd-Ellatef GEF, 2017, BREAST CANCER-TARGET, V9, P67, DOI 10.2147/BCTT.S125165
[2]   In vitro cytotoxicity and pro-apoptotic activity of phycocyanin nanoparticles from Ulva lactuca (Chlorophyta) algae [J].
Al-Malki, Abdulrahman L. .
SAUDI JOURNAL OF BIOLOGICAL SCIENCES, 2020, 27 (03) :894-898
[3]   From Marine Origin to Therapeutics: The Antitumor Potential of Marine Algae-Derived Compounds [J].
Alves, Celso ;
Silva, Joana ;
Pinteus, Susete ;
Gaspar, Helena ;
Alpoim, Maria C. ;
Botana, Luis M. ;
Pedrosa, Rui .
FRONTIERS IN PHARMACOLOGY, 2018, 9
[4]   Bifurcaria bifurcata: a key macro-alga as a source of bioactive compounds and functional ingredients [J].
Alves, Celso ;
Pinteus, Susete ;
Simoes, Tiago ;
Horta, Andre ;
Silva, Joana ;
Tecelao, Carla ;
Pedrosa, Rui .
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 2016, 51 (07) :1638-1646
[5]  
Aslanturk O.S., 2018, In Vitro Cytotoxicity and Cell Viability Assays: Disadvantages
[6]   Evaluation of the anticancer potential of Hexadecanoic acid from brown algae Turbinaria ornata on HT-29 colon cancer cells [J].
Bharath, Boobalan ;
Perinbam, Kantharaj ;
Devanesan, Sandhanasamy ;
AlSalhi, Mohamad S. ;
Saravanan, Muthupandian .
JOURNAL OF MOLECULAR STRUCTURE, 2021, 1235
[7]   Marine natural products [J].
Blunt, John W. ;
Copp, Brent R. ;
Keyzers, Robert A. ;
Munro, Murray H. G. ;
Prinsep, Michele R. .
NATURAL PRODUCT REPORTS, 2015, 32 (02) :116-211
[8]   Biologically Active Metabolites Synthesized by Microalgae [J].
de Morais, Michele Greque ;
Vaz, Bruna de Silva ;
de Morais, Etiele Greque ;
Vieira Costa, Jorge Alberto .
BIOMED RESEARCH INTERNATIONAL, 2015, 2015
[9]   Algae biopolymer towards sustainable circular economy [J].
Devadas, Vishno Vardhan ;
Khoo, Kuan Shiong ;
Chia, Wen Yi ;
Chew, Kit Wayne ;
Munawaroh, Heli Siti Halimatul ;
Lam, Man-Kee ;
Lim, Jun-Wei ;
Ho, Yeek-Chia ;
Lee, Keat Teong ;
Show, Pau Loke .
BIORESOURCE TECHNOLOGY, 2021, 325 (325)
[10]  
Gazali M., 2019, V278, P012029, DOI 10.1088/1755-1315/278/1/012029
1234