Ticagrelor Versus Prasugrel in Patients With Acute Coronary Syndrome: A Systematic Review and Meta-Analysis

被引：4

作者：

Shah, Rajendra P. ^{[1
]}

Shafiq, Aimen ^{[2
]}

Hamza, Mohammad ^{[3
]}

Maniya, Muhammad Talha ^{[4
]}

Duhan, Sanchit ^{[5
]}

Keisham, Bijeta ^{[5
]}

Patel, Bansari ^{[6
]}

Alamzaib, Sardar Muhammad ^{[7
]}

Yashi, Kanica ^{[8
]}

Uppal, Dipan ^{[9
]}

Sattar, Yasar ^{[10
]}

Tiwari, Dinesh ^{[11
]}

Paul, Timir K. ^{[12
]}

AlJaroudi, Wael ^{[13
]}

Alraies, M. Chadi ^{[1
,14
]}

机构：

[1] Univ Florida, Malcom Randall Vet Affairs Med Ctr, Dept Cardiol, Gainesville, FL USA

[2] Dow Univ Hlth Sci, Dept Med, Karachi, Pakistan

[3] Albany Med Ctr, Dept Med, Albany, NY USA

[4] Ziauddin Med Univ, Dept Med, Karachi, Pakistan

[5] Sinai Hosp Baltimore, Dept Med, Baltimore, MD USA

[6] West Virginia Univ, Dept Med, Morgantown, WV USA

[7] Marshall Univ, Sch Med, Dept Cardiol, Huntington, WV USA

[8] Bassett Healthcare, Dept Med, Cooperstown, NY USA

[9] Cleveland Clin Florida, Dept Cardiol, Weston, FL USA

[10] West Virginia Univ, Dept Cardiol, Morgantown, WV USA

[11] Mayo Inst Med Sci, Dept Dermatol, Barabanki, Uttar Pradesh, India

[12] Univ Tennessee, Hlth Sci Ctr, Dept Cardiol, Nashville, TN USA

[13] Augusta Univ, Med Coll Georgia, Div Cardiol, Augusta, GA USA

[14] Detroit Med Ctr, Cardiovasc Inst, Dept Cardiol, Detroit, MI 48201 USA

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2023年 / 207卷

关键词：

angioplasty; balloon; coronary artery; myocardial infarction; percutaneous coronary intervention; CLINICAL-TRIALS;

D O I：

10.1016/j.amjcard.2023.08.117

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Limited data comparing prasugrel and ticagrelor in acute coronary syndrome are available. Online databases, including MEDLINE and Cochrane Central, were queried to compare these drugs. The primary outcomes of this meta-analysis are myocardial infarction (MI), all-cause mortality, cardiovascular mortality, noncardiovascular mortality, stent thrombosis, and stroke. The secondary outcome is major bleeding. A total of 9 studies, including 94,590 patients (prasugrel group = 32,759; ticagrelor group = 61,831), were included in this meta-analysis. The overall mean age was 62.73 years, whereas the mean age for the ticagrelor and prasugrel groups was 63.80 and 61.65 years, respectively. Prasugrel is equally effective as compared with ticagrelor in preventing MI. There was no difference between the 2 groups regarding all-cause mortality, stent thrombosis, stroke, or major bleeding. In patients with acute coronary syndrome, prasugrel is equally effective when compared with ticagrelor in preventing MI. (c) 2023 Published by Elsevier Inc. (Am J Cardiol 2023;207:206-214)

引用

页码：206 / 214

页数：9

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