Treatment of berberine alleviates diabetic nephropathy by reducing iron overload and inhibiting oxidative stress

被引：9
作者：
Wang, Yujing [1 ]
Yue, Shuling [2 ]
Cai, Feng [3 ]
Zhu, Wen [4 ]
Zhong, Yuxiang [1 ]
Chen, Juanjuan [1 ]
Li, Chunyun [5 ,6 ]
机构：
[1] Cent South Univ, Haikou Affiliated Hosp, Xiangya Sch Med, Dept Hemodialysis, Changsha, Peoples R China
[2] King Med Diagnost Ctr, Dept Renal Pathol, Guangzhou, Peoples R China
[3] Cent South Univ, Haikou Affiliated Hosp, Xiangya Sch Med, Dept Opthalmol, Changsha, Peoples R China
[4] Hainan Univ, Coll Trop Crops, Hainan, Peoples R China
[5] Cent South Univ, Haikou Affiliated Hosp, Xiangya Sch Med, Clin Lab, Xiangya, Peoples R China
[6] Cent South Univ, Haikou Affiliated Hosp, Xiangya Sch Med, Clin Lab, Xiangyang 570208, Peoples R China
来源：
HISTOLOGY AND HISTOPATHOLOGY | 2023年 / 38卷 / 09期
关键词：
Diabetic nephropathy; Iron overload; Oxidative stress; Berberine; DEFERIPRONE; EXPRESSION; CHELATOR;
D O I：
10.14670/HH-18-599
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
. Diabetic nephropathy (DN) has become one of the major fatal factors in diabetic patients. The aim of this study was to elucidate the function and mechanism by which berberine exerts renoprotective effects in DN. In this work, we first demonstrated that urinary iron concentration, serum ferritin and hepcidin levels were increased and total antioxidant capacity was significantly decreased in DN rats, while these changes could be partially reversed by berberine treatment. Berberine treatment also alleviated DN-induced changes in the expression of proteins involved in iron transport or iron uptake. In addition, berberine treatment also partially blocked the expression of renal fibrosis markers induced by DN, including MMP2, MMP9, TIMP3, beta-arrestin-1, and TGF-beta 1. In conclusion, the results of this study suggest that berberine may exert renoprotective effects by ameliorating iron overload and oxidative stress and reducing DN.
引用
收藏
页码：1009 / 1016
页数：8
相关论文
共 44 条
[1]   AKI Associated with Macroscopic Glomerular Hematuria: Clinical and Pathophysiologic Consequences [J].
Antonio Moreno, Juan ;
Martin-Cleary, Catalina ;
Gutierrez, Eduardo ;
Toldos, Oscar ;
Miguel Blanco-Colio, Luis ;
Praga, Manuel ;
Ortiz, Alberto ;
Egido, Jesus .
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2012, 7 (01) :175-184
[2]   An Update on the Use of Animal Models in Diabetic Nephropathy Research [J].
Betz, Boris ;
Conway, Bryan R. .
CURRENT DIABETES REPORTS, 2016, 16 (02) :1-9
[3]   Macrophage Phenotype and Fibrosis in Diabetic Nephropathy [J].
Calle, Priscila ;
Hotter, Georgina .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (08)
[4]   Berberine as a therapy for type 2 diabetes and its complications: From mechanism of action to clinical studies [J].
Chang, Wenguang ;
Chen, Li ;
Hatch, Grant M. .
BIOCHEMISTRY AND CELL BIOLOGY, 2015, 93 (05) :479-486
[5]   Genetics of diabetes mellitus and diabetes complications [J].
Cole, Joanne B. ;
Florez, Jose C. .
NATURE REVIEWS NEPHROLOGY, 2020, 16 (07) :377-390
[6]   Renal iron overload in rats with diabetic nephropathy [J].
Dominguez, Jesus H. ;
Liu, Yunlong ;
Kelly, Katherine. J. .
PHYSIOLOGICAL REPORTS, 2015, 3 (12)
[7]   Iron homeostasis and oxidative stress: An intimate relationship [J].
Galaris, Dimitrios ;
Barbouti, Alexandra ;
Pantopoulos, Kostas .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2019, 1866 (12)
[8]   Quantitative magnetic analysis reveals ferritin-like iron as the most predominant iron-containing species in the murine Hfe-haemochromatosis [J].
Gutierrez, Lucia ;
Spasic, Maja Vujic ;
Muckenthaler, Martina U. ;
Lazaro, Francisco J. .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2012, 1822 (07) :1147-1153
[9]  
Hashemieh M, 2012, ARCH IRAN MED, V15, P91, DOI 012152/AIM.009
[10]   A holistic view of mammalian (vertebrate) cellular iron uptake [J].
Kosman, Daniel J. .
METALLOMICS, 2020, 12 (09) :1323-1334
12345