Enhanced Photodynamic Therapy by Improved Light Energy Capture Efficiency of Porphyrin Photosensitizers

被引：18

作者：

Tian, Zejie ^{[1
,2
]}

Li, Hui ^{[1
,2
]}

Liu, Zhenhua ^{[1
,2
]}

Yang, Lingyan ^{[1
,2
]}

Zhang, Chaoyang ^{[3
]}

He, Jun ^{[3
]}

Ai, Wenbin ^{[4
]}

Liu, Yunmei ^{[1
,2
]}

机构：

[1] Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, 28 Changsheng Rd, Hengyang 421001, Hunan, Peoples R China

[2] Hunan Prov Key Lab Tumor Microenvironm Respons Dru, Changsheng Rd, Hengyang 421001, Hunan, Peoples R China

[3] Univ South China, Inst Chem & Chem Engn, Hengyang 421001, Hunan, Peoples R China

[4] Univ South China, Affiliated Hosp 2, Hengyang 421001, Hunan, Peoples R China

来源：

CURRENT TREATMENT OPTIONS IN ONCOLOGY | 2023年 / 24卷 / 09期

关键词：

Cancer; Photodynamic therapy; Photosensitizers; Porphyrin; SINGLET OXYGEN GENERATION; NEAR-INFRARED ABSORBENCY; DRUG-DELIVERY; SUPRAMOLECULAR PHOTOSENSITIZERS; POLYMER NANOPARTICLES; SILICA NANOPARTICLES; 2-PHOTON ABSORPTION; CELLULAR UPTAKE; CANCER; OXIDE;

D O I：

10.1007/s11864-023-01120-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Opinion Statement Photodynamic therapy (PDT) has garnered increasing attention in cancer treatment because of its advantages such as minimal invasiveness and selective destruction. With the development of PDT, impressive progress has been made in the preparation of photosensitizers, particularly porphyrin photosensitizers. However, the limited tissue penetration of the activating light wavelengths and relatively low light energy capture efficiency of porphyrin photosensitizers are two major disadvantages in conventional photosensitizers. Therefore, tissue penetration needs to be enhanced and the light energy capture efficiency of porphyrin photosensitizers improved through structural modifications. The indirect excitation of porphyrin photosensitizers using fluorescent donors (fluorescence resonance energy transfer) has been successfully used to address these issues. In this review, the enhancement of the light energy capture efficiency of porphyrins is discussed.

引用

页码：1274 / 1292

页数：19

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