What is cancer metabolism?

被引：167

作者：

Finley, Lydia W. S. ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Cell Biol Program, New York, NY 10065 USA

来源：

CELL | 2023年 / 186卷 / 08期

关键词：

CELLULAR-METABOLISM; EPIGENETIC MODIFIER; SERINE SYNTHESIS; REDOX STATE; TCA CYCLE; GROWTH; REVEALS; TRANSPORT; FUMARATE; HYPOXIA;

D O I：

10.1016/j.cell.2023.01.038

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The uptake and metabolism of nutrients support fundamental cellular process from bioenergetics to biomass production and cell fate regulation. While many studies of cell metabolism focus on cancer cells, the principles of metabolism elucidated in cancer cells apply to a wide range of mammalian cells. The goal of this review is to discuss how the field of cancer metabolism provides a framework for revealing principles of cell metabolism and for dissecting the metabolic networks that allow cells to meet their specific demands. Understanding context-specific metabolic preferences and liabilities will unlock new approaches to target cancer cells to improve patient care.

引用

页码：1670 / 1688

页数：19

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