Enzyme-bimetallic hybrid catalyst for one-pot chemoenzymatic reactions

被引：22

作者：

Li, Xiaoyang ^{[1
]}

Hu, Xinyu ^{[1
]}

Qiao, Yida ^{[2
]}

Lu, Tianying ^{[1
]}

Bai, Yunxiu ^{[2
]}

Xiong, Jiarong ^{[2
]}

Li, Xinyang ^{[3
]}

Gou, Qingqiang ^{[3
]}

Ge, Jun ^{[2
,4
,5
]}

机构：

[1] Nanchang Univ, Sch Food Sci & Technol, State Key Lab Food Sci & Technol, Nanchang 330047, Peoples R China

[2] Tsinghua Univ, Dept Chem Engn, Minist Educ, Key Lab Ind Biocatalysis, Beijing 100084, Peoples R China

[3] SINOPEC Beijing Res Inst Chem Ind Co Ltd, Beijing 100084, Peoples R China

[4] Tsinghua Shenzhen Int Grad Sch, Inst Biopharmaceut & Hlth Engn, Shenzhen 518055, Peoples R China

[5] Inst Biomed Hlth Technol & Engn, Shenzhen Bay Lab, Shenzhen 518107, Peoples R China

来源：

CHEMICAL ENGINEERING JOURNAL | 2023年 / 452卷

基金：

中国国家自然科学基金;

关键词：

Chemoenzymatic catalysis; One -pot reaction; Enzyme -metal hybrid catalyst; Bimetallic alloy; Cooperative catalysis; NANOPARTICLES; METAL;

D O I：

10.1016/j.cej.2022.139356

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

To overcome the intrinsic incompatibility between enzyme and chemical catalysts in one-pot chemoenzymatic cascade reactions, an enzyme-bimetallic hybrid catalyst was constructed by in situ reduction of ultrafine PdCu naonoclusters on the cross-linked lipase aggregates. The PdCu nanoalloy showed excellent activity in the Sonogashira coupling reaction because of the strong bimetallic synergistic effect between Pd and Cu within PdCu/CALB CLEAs. The activity of 3.4Pd1.7Cu/CALB CLEAs was 2.6-fold of Pd/CALB CLEAs in the synthesis of (R)-N-[1-(4-(phenylethynyl)phenyl)ethyl] acetamide. The highly active PdCu/CALB CLEAs rendered the one-pot chemoenzymatic reaction to perform at a lower temperature.

引用

页数：6

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