The role of bone marrow microenvironment (BMM) cells in acute myeloid leukemia (AML) progression: immune checkpoints, metabolic checkpoints, and signaling pathways

被引：34

作者：

Bakhtiyari, Maryam ^{[1
,2
]}

Liaghat, Mahsa ^{[2
,3
]}

Aziziyan, Fatemeh ^{[2
,4
]}

Shapourian, Hooriyeh ^{[5
]}

Yahyazadeh, Sheida ^{[6
]}

Alipour, Maedeh ^{[7
]}

Shahveh, Shaghayegh ^{[8
]}

Maleki-Sheikhabadi, Fahimeh ^{[9
]}

Halimi, Hossein ^{[6
]}

Forghaniesfidvajani, Razieh ^{[2
]}

Zalpoor, Hamidreza ^{[2
,10
]}

Nabi-Afjadi, Mohsen ^{[4
]}

Pornour, Majid ^{[11
,12
]}

机构：

[1] Qazvin Univ Med Sci, Fac Allied Med, Dept Med Lab Sci, Qazvin, Iran

[2] Universal Sci Educ & Res Network USERN, Network Immun Infect Malignancy & Autoimmun NIIMA, Tehran, Iran

[3] Islamic Azad Univ, Fac Med Sci, Dept Med Lab Sci, Kazerun Branch, Kazerun, Iran

[4] Tarbiat Modares Univ, Fac Biol Sci, Dept Biochem, Tehran, Iran

[5] Isfahan Univ Med Sci, Fac Med, Dept Immunol, Esfahan, Iran

[6] Shiraz Univ Med Sci, Sch Med, Dept Immunol, Shiraz, Iran

[7] Babol Univ Med Sci, Hlth Res Inst, Cellular & Mol Biol Res Ctr, Babol, Iran

[8] Amer Assoc Naturopath Phys AANP, Washington, DC USA

[9] Shiraz Univ Med Sci, Sch Paramed Sci, Dept Hematol & Blood Banking, Shiraz, Iran

[10] Shiraz Univ Med Sci, Shiraz Neurosci Res Ctr, Shiraz, Iran

[11] Univ Maryland, Dept Biochem & Mol Biol, Baltimore, MD 21201 USA

[12] Marlene & Stewart Greenebaum Comprehens Canc Ctr, Baltimore, MD 21201 USA

来源：

CELL COMMUNICATION AND SIGNALING | 2023年 / 21卷 / 01期

关键词：

Acute myeloid leukemia; Bone marrow microenvironment; Cancer metabolism; Metabolic checkpoint; Immune checkpoint; Angiogenesis; Chemoresistance; HEMATOPOIETIC STEM-CELL; FATTY-ACID OXIDATION; MESENCHYMAL STROMAL CELLS; ENDOTHELIAL GROWTH-FACTOR; NATURAL-KILLER-CELLS; REGULATORY T-CELLS; CHAPERONE-MEDIATED AUTOPHAGY; PEGYLATED ARGININE DEIMINASE; ALTERED GLUCOSE-METABOLISM; DENDRITIC CELLS;

D O I：

10.1186/s12964-023-01282-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Acute myeloid leukemia (AML) comprises a multifarious and heterogeneous array of illnesses characterized by the anomalous proliferation of myeloid cells in the bone marrow microenvironment (BMM). The BMM plays a pivotal role in promoting AML progression, angiogenesis, and metastasis. The immune checkpoints (ICs) and metabolic processes are the key players in this process. In this review, we delineate the metabolic and immune checkpoint characteristics of the AML BMM, with a focus on the roles of BMM cells e.g. tumor-associated macrophages, natural killer cells, dendritic cells, metabolic profiles and related signaling pathways. We also discuss the signaling pathways stimulated in AML cells by BMM factors that lead to AML progression. We then delve into the roles of immune checkpoints in AML angiogenesis, metastasis, and cell proliferation, including co-stimulatory and inhibitory ICs. Lastly, we discuss the potential therapeutic approaches and future directions for AML treatment, emphasizing the potential of targeting metabolic and immune checkpoints in AML BMM as prognostic and therapeutic targets. In conclusion, the modulation of these processes through the use of directed drugs opens up new promising avenues in combating AML. Thereby, a comprehensive elucidation of the significance of these AML BMM cells' metabolic and immune checkpoints and signaling pathways on leukemic cells can be undertaken in the future investigations. Additionally, these checkpoints and cells should be considered plausible multi-targeted therapies for AML in combination with other conventional treatments in AML.4fLEX7tLHnLn8Cp1swJnhpVideo Abstract

引用

页数：38

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