Ferroptosis as a potential target for cancer therapy

被引：122

作者：

Chen, Zhen ^{[1
,2
,3
]}

Wang, Weilong ^{[1
,2
,3
]}

Abdul Razak, Siti Razila ^{[2
]}

Han, Tao ^{[1
,3
,4
]}

Ahmad, Nor Hazwani ^{[2
]}

Li, Xiumin ^{[1
,3
]}

机构：

[1] Xinxiang Med Univ, Affiliated Hosp 3, Dept Gastroenterol, Henan Key Lab Tumor Mol Therapy Med, Xinxiang 453003, Henan, Peoples R China

[2] Univ Sains Malaysia, Adv Med & Dent Inst, Dept Biomed Sci, Kepala Batas 13200, Pulau Pinang, Malaysia

[3] Xinxiang Med Univ, Xinxiang Key Lab Mol Therapy Canc, Xinxiang 453003, Henan, Peoples R China

[4] Xinxiang Med Univ, Inst Hlth Cent Plains, Xinxiang 453003, Henan, Peoples R China

来源：

CELL DEATH & DISEASE | 2023年 / 14卷 / 07期

关键词：

MOLECULAR-MECHANISMS; LIPID-PEROXIDATION; HIPPO PATHWAY; CELLS; IRON; APOPTOSIS; METABOLISM; RESISTANCE; PYROPTOSIS; CARCINOMA;

D O I：

10.1038/s41419-023-05930-w

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Ferroptosis is a recently discovered essential type of cell death that is mainly characterized by iron overload and lipid peroxidation. Emerging evidence suggests that ferroptosis is a double-edged sword in human cancer. However, the precise underlying molecular mechanisms and their differential roles in tumorigenesis are unclear. Therefore, in this review, we summarize and briefly present the key pathways of ferroptosis, paying special attention to the regulation of ferroptosis as well as its dual role as an oncogenic and as a tumor suppressor event in various human cancers. Moreover, multiple pharmacological ferroptosis activators are summarized, and the prospect of targeting ferroptosis in cancer therapy is further elucidated.

引用

页数：15

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