Reuniting philosophy and science to advance cancer research

被引：10

作者：

Pradeu, Thomas ^{[1
,2
]}

Daignan-Fornier, Bertrand ^{[3
]}

Ewald, Andrew ^{[4
]}

Germain, Pierre-Luc ^{[5
,6
]}

Okasha, Samir ^{[7
]}

Plutynski, Anya ^{[8
,9
]}

Benzekry, Sebastien ^{[10
]}

Bertolaso, Marta ^{[11
,12
]}

Bissell, Mina ^{[13
]}

Brown, Joel S. ^{[14
]}

Chin-Yee, Benjamin ^{[15
,16
]}

Chin-Yee, Ian ^{[17
]}

Clevers, Hans ^{[18
,19
,20
]}

Cognet, Laurent ^{[21
]}

Darrason, Marie ^{[22
,23
]}

Farge, Emmanuel ^{[24
]}

Feunteun, Jean ^{[25
]}

Galon, Jerome ^{[26
]}

Giroux, Elodie ^{[23
]}

Green, Sara ^{[27
]}

Gross, Fridolin ^{[1
]}

Jaulin, Fanny ^{[28
]}

Knight, Rob ^{[29
,30
,31
]}

Laconi, Ezio ^{[32
]}

Larmonier, Nicolas ^{[1
]}

Maley, Carlo ^{[33
,34
,35
,36
,37
]}

Mantovani, Alberto ^{[38
,39
,40
]}

Moreau, Violaine ^{[41
]}

Nassoy, Pierre ^{[21
]}

Rondeau, Elena ^{[42
,43
]}

Santamaria, David ^{[44
]}

Sawai, Catherine M. ^{[41
]}

Seluanov, Andrei ^{[45
]}

Sepich-Poore, Gregory D. ^{[46
]}

Sisirak, Vanja ^{[1
]}

Solary, Eric ^{[47
,48
,49
]}

Yvonnet, Sarah ^{[50
]}

Laplane, Lucie ^{[2
,47
,51
]}

机构：

[1] Univ Bordeaux, CNRS UMR5164 ImmunoConcEpT, 146 Rue Leo Saignat, F-33076 Bordeaux, France

[2] Univ Paris I Pantheon Sorbonne, Inst Hist & Philosophie Sci & Tech, CNRS UMR8590, 13 Rue Four, F-75006 Paris, France

[3] Univ Bordeaux, CNRS UMR 5095 Inst Biochim & Genet Cellulaires, 1 Rrue Camille St Saens, F-33077 Bordeaux, France

[4] Johns Hopkins Univ, Sch Med, Dept Cell Biol & Oncol, Baltimore, MD 21205 USA

[5] Eidgenoss TH ETH Zurich, Inst Neurosci, Dept Hlth Sci & Technol, Univ Str 2, CH-8092 Zurich, Switzerland

[6] Univ Zurich, Dept Mol Life Sci, Lab Stat Bioinformat, Winterthurerstr 190, CH-8057 Zurich, Switzerland

[7] Univ Bristol, Dept Philosophy, Cotham House, Bristol BS6 6JL, England

[8] Washington Univ St Louis, Dept Philosophy, St Louis, MO 63105 USA

[9] Div Biol & Biomed Sci, St Louis, MO 63105 USA

[10] Aix Marseille Univ UM105, Computat Pharmacol & Clin Oncol COMPO Unit, Inria Sophia Antipolis Mediterranee, Canc Res Ctr Marseille,Inserm UMR1068,CNRS UMR725, 27 Bd Jean Moulin, F-13005 Marseille, France

[11] Univ Campus Biomed Roma, Res Unit Philosophy Sci & Human Dev, Via Alvaro Portillo 21, I-00128 Rome, Italy

[12] Univ Bergen, Ctr Canc Biomarkers, N-5007 Bergen, Norway

[13] Lawrence Berkeley Natl Lab, Biol Syst & Engn Div, 1 Cyclotron Rd, Berkeley, CA 94720 USA

[14] H Lee Moffitt Canc Ctr & Res Inst, Dept Integrated Math Oncol, Tampa, FL USA

[15] Western Univ, Schulich Sch Med & Dent, Dept Med, Div Hematol, 800 Commissioners Rd E, London, ON, Canada

[16] Western Univ, Rotman Inst Philosophy, 1151 Richmond St North, London, ON, Canada

[17] Western Univ, Schulich Sch Med & Dent, Dept Pathol & Lab Med, 800 Commissioners Rd E, London, ON, Canada

[18] F Hoffmann La Roche Ltd, Pharm Res & Early Dev pRED, Grenzacherstr 124, CH-4070 Basel, Switzerland

[19] Royal Netherlands Acad Arts & Sci, Oncode Inst, Hubrecht Inst, Uppsalalaan 8, NL-3584 CT Utrecht, Netherlands

[20] Univ Med Ctr, Uppsalalaan 8, NL-3584 CT Utrecht, Netherlands

[21] Univ Bordeaux, CNRS UMR 5298, Lab Photon Numer & Nanosci, Rue Francois Mitterrand, F-33400 Talence, France

[22] Univ Hosp Lyon, Dept Pneumol & Thorac Oncol, 165 Chem Grand Revoyet, F-69310 Lyon, France

[23] Lyon 3 Jean Moulin Univ, Lyon Inst Philosoph Res, 1 Ave Freres Lumiere, F-69007 Lyon, France

[24] Sorbonne Univ, Mech & Genet Embryon & Tumor Dev Grp, Inst Curie, CNRS,UMR168,Inserm,Ctr Origines & Condit Apparit, 11 Rue Pierre & Marie Curie, F-75005 Paris, France

[25] Gustave Roussy, INSERM U981, 114 Rue Edouard Vaillant, F-94800 Villejuif, France

[26] Sorbonne Univ, INSERM UMRS1138, Integrat Canc Immunol, Cordelier Res Ctr,Univ Paris Cite, 15 Rue Ecole Medecine, F-75006 Paris, France

[27] Univ Copenhagen, Dept Sci Educ, Sect Hist & Philosophy Sci, Radmandsgade 64, DK-2200 Copenhagen, Denmark

[28] Gustave Roussy, INSERM U1279, 114 Rue Edouard Vaillant, F-94800 Villejuif, France

[29] Univ Calif San Diego, Dept Bioengn, 3223 Voigt Dr, La Jolla, CA 92093 USA

[30] Univ Calif San Diego, Dept Pediat, La Jolla, CA 92093 USA

[31] Univ Calif San Diego, Dept Comp Sci & Engn, La Jolla, CA 92093 USA

[32] Univ Cagliari, Sch Med, Dept Biomed Sci, Via Univ 40, I-09124 Cagliari, Italy

[33] Arizona State Univ, Arizona Canc Evolut Ctr, 427 East Tyler Mall, Tempe, AZ 85287 USA

[34] Arizona State Univ, Sch Life Sci, 427 East Tyler Mall, Tempe, AZ 85287 USA

[35] Arizona State Univ, Biodesign Ctr Biocomp Secur & Soc, 1001 S McAllister Ave, Tempe, AZ 85287 USA

[36] Arizona State Univ, Biodesign Ctr Mech Evolut, 1001 S McAllister Ave, Tempe, AZ 85287 USA

[37] Arizona State Univ, Ctr Evolut & Med, 427 East Tyler Mall, Tempe, AZ 85287 USA

[38] Humanitas Univ, Dept Biomed Sci, 4 Via R Levi Montalcini, I-20090 Milan, Italy

[39] Ist Clin Humanitas Canc Ctr IRCCS Humanitas Res H, Dept Immunol & Inflammat, Via Manzoni 56, I-20089 Milan, Italy

[40] Queen Mary Univ London, William Harvey Res Inst, London EC1M 6BQ, England

[41] Univ Bordeaux, Bordeaux Inst Oncol BRIC, INSERM UMR1312, 146 Rue Leo Saignat, F-33076 Bordeaux, France

[42] ENS Lyon, INSERM U1111, 46 Allee Italie, F-69007 Lyon, France

[43] Ctr Int Rech Infectionl CIRI, 46 Allee Italie, F-69007 Lyon, France

[44] Consejo Super Invest Cient CSIC Univ Salamanca, Ctr Invest Canc, Mol Mech Canc Program, Salamanca 37007, Spain

[45] Univ Rochester, Dept Biol & Med, Rochester, NY 14627 USA

[46] Micronoma, 6342 Ferris Sq, San Diego, CA 92121 USA

[47] Gustave Roussy, INSERM U1287, 114 Rue Edouard Vaillant, F-94800 Villejuif, France

[48] Gustave Roussy, Dept Hematol, 114 Rue Edouard Vaillant, F-94800 Villejuif, France

[49] Univ Paris Saclay, Fac Med, 63 Rue Gabriel Peri, F-94270 Le Kremlin Bicetre, France

[50] Univ Copenhagen, Novo Nord Fdn Ctr Basic Metab Res, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark

来源：

BIOLOGICAL REVIEWS | 2023年 / 98卷 / 05期

关键词：

driver mutation; clonal evolution; multicellularity; tumorigenesis; tumour microenvironment; oncoimmunology; cancer stem cells; philosophy of cancer; CLONAL EVOLUTION; PASSENGER MUTATIONS; STEM-CELLS; IMMUNE RECOGNITION; GENETIC THEORY; TUMOR; SELECTION; PROGRESSION; METASTASIS; DYNAMICS;

D O I：

10.1111/brv.12971

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cancers rely on multiple, heterogeneous processes at different scales, pertaining to many biomedical fields. Therefore, understanding cancer is necessarily an interdisciplinary task that requires placing specialised experimental and clinical research into a broader conceptual, theoretical, and methodological framework. Without such a framework, oncology will collect piecemeal results, with scant dialogue between the different scientific communities studying cancer. We argue that one important way forward in service of a more successful dialogue is through greater integration of applied sciences (experimental and clinical) with conceptual and theoretical approaches, informed by philosophical methods. By way of illustration, we explore six central themes: (i) the role of mutations in cancer; (ii) the clonal evolution of cancer cells; (iii) the relationship between cancer and multicellularity; (iv) the tumour microenvironment; (v) the immune system; and (vi) stem cells. In each case, we examine open questions in the scientific literature through a philosophical methodology and show the benefit of such a synergy for the scientific and medical understanding of cancer.

引用

页码：1668 / 1686

页数：19

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