Gut microbiota, a hidden protagonist of traditional Chinese medicine for acute ischemic stroke

被引：9

作者：

Gao, Lin ^{[1
,3
]}

Xia, Xiuwen ^{[2
]}

Shuai, Yinqi ^{[1
,3
]}

Zhang, Hong ^{[1
]}

Jin, Wei ^{[1
]}

Zhang, Xiaoyun ^{[1
]}

Zhang, Yi ^{[4
]}

机构：

[1] Chengdu Univ Tradit Chinese Med, Emergency Dept, Affiliated Hosp, Chengdu, Sichuan, Peoples R China

[2] Chengdu Univ Tradit Chinese Med, Sch Basic Med Sci, Chengdu, Sichuan, Peoples R China

[3] Chengdu Univ Tradit Chinese Med, Sch Clin Med, Chengdu, Sichuan, Peoples R China

[4] Chengdu Univ Tradit Chinese Med, Geriatr Dept, Affiliated Hosp, Chengdu, Sichuan, Peoples R China

来源：

FRONTIERS IN PHARMACOLOGY | 2023年 / 14卷

关键词：

acute ischemic stroke (AIS); traditional Chinese medicine (TCM); gut microbiota; Chinese herbs; brain-gut-microbe axis (BGMAs); immunology and inflammation; intestinal barrier; microbial metabolites; TRIMETHYLAMINE N-OXIDE; INTESTINAL MICROBIOTA; CEREBRAL-ISCHEMIA; T-CELLS; COMMENSAL BACTERIA; REPERFUSION INJURY; ACID-METABOLISM; BRAIN-INJURY; L-CARNITINE; DECOCTION;

D O I：

10.3389/fphar.2023.1164150

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Acute ischemic stroke (AIS) is one of the leading diseases causing death and disability worldwide, and treatment options remain very limited. Traditional Chinese Medicine (TCM) has been used for thousands of years to treat ischemic stroke and has been proven to have significant efficacy, but its mechanism of action is still unclear. As research related to the brain-gut-microbe axis progresses, there is increasing evidence that the gut microbiota plays an important role during AIS. The interaction between TCM and the gut microbiota has been suggested as a possible key link to the therapeutic effects of TCM. We have compiled and reviewed recent studies on the relationship between AIS, TCM, and gut microbiota, with the expectation of providing more ideas to elucidate the mechanism of action of TCM in the treatment of AIS.

引用

页数：17

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