The impact of obesity on lung function measurements and respiratory disease: A Mendelian randomization study

被引:5
作者
Liu, Jiayan [1 ]
Xu, Hanfei [2 ,5 ]
Cupples, L. Adrienne [2 ]
O' Connor, George T. [3 ,4 ]
Liu, Ching-Ti [2 ,5 ]
机构
[1] Brigham & Womens Hosp, Div Sleep Med, Boston, MA USA
[2] Boston Univ, Dept Biostat, Sch Publ Hlth, Boston, MA USA
[3] Boston Univ, Pulm Ctr, Sch Med, Boston, MA USA
[4] Boston Med Ctr, Div Pulm Allergy Sleep & Crit Care Med, Boston, MA USA
[5] Boston Univ, Dept Biostat, Sch Publ Hlth, Boston, MA 02215 USA
关键词
BODY-MASS INDEX; PULMONARY-FUNCTION; FAT DISTRIBUTION; ASTHMA; BIAS;
D O I
10.1111/ahg.12506
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
IntroductionObservational studies have shown that body mass index (BMI) and waist-to-hip ratio (WHR) are both inversely associated with lung function, as assessed by forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1). However, observational data are susceptible to confounding and reverse causation. MethodsWe selected genetic instruments based on their relevant large-scale genome-wide association studies. Summary statistics of lung function and asthma came from the UK Biobank and SpiroMeta Consortium meta-analysis (n = 400,102). After examining pleiotropy and removing outliers, we applied inverse-variance weighting to estimate the causal association of BMI and BMI-adjusted WHR (WHRadjBMI) with FVC, FEV1, FEV1/FVC, and asthma. Sensitivity analyses were performed using weighted median, MR-Egger, and MRlap methods. ResultsWe found that BMI was inversely associated with FVC (effect estimate, -0.167; 95% confidence interval (CI), -0.203 to -0.130) and FEV1 (effect estimate, -0.111; 95%CI, -0.149 to -0.074). Higher BMI was associated with higher FEV1/FVC (effect estimate, 0.079; 95%CI, 0.049 to 0.110) but was not significantly associated with asthma. WHRadjBMI was inversely associated with FVC (effect estimate, -0.132; 95%CI, -0.180 to -0.084) but has no significant association with FEV1. Higher WHR was associated with higher FEV1/FVC (effect estimate, 0.181; 95%CI, 0.130 to 0.232) and with increased risk of asthma (effect estimate, 0.027; 95%CI, 0.001 to 0.053). ConclusionWe found significant evidence that increased BMI is suggested to be causally related to decreased FVC and FEV1, and increased BMI-adjusted WHR could lead to lower FVC value and higher risk of asthma. Higher BMI and BMI-adjusted WHR were suggested to be causally associated with higher FEV1/FVC.
引用
收藏
页码:174 / 183
页数:10
相关论文
共 38 条
[1]   Association of Body Mass Index (BMI) with Lung Function Parameters in Non-asthmatics Identified by Spirometric Protocols [J].
Banerjee, Joyashree ;
Roy, Anindya ;
Singhamahapatra, Anilbaran ;
Dey, Pranab Kumar ;
Ghosal, Achyut ;
Das, Anubrata .
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2014, 8 (02) :12-14
[2]   Asthma and Obesity: Two Diseases on the Rise and Bridged by Inflammation [J].
Bantula, Marina ;
Roca-Ferrer, Jordi ;
Arismendi, Ebymar ;
Picado, Cesar .
JOURNAL OF CLINICAL MEDICINE, 2021, 10 (02) :1-21
[3]   Exploiting collider bias to apply two-sample summary data Mendelian randomization methods to one-sample individual level data [J].
Barry, Ciarrah ;
Liu, Junxi ;
Richmond, Rebecca ;
Rutter, Martin K. ;
Lawlor, Deborah A. ;
Dudbridge, Frank ;
Bowden, Jack .
PLOS GENETICS, 2021, 17 (08)
[4]   Body size and physical activity in relation to incidence of chronic obstructive pulmonary disease [J].
Behrens, Gundula ;
Matthews, Charles E. ;
Moore, Steven C. ;
Hollenbeck, Albert R. ;
Leitzmann, Michael F. .
CANADIAN MEDICAL ASSOCIATION JOURNAL, 2014, 186 (12) :E457-E469
[5]   Overweight, obesity, and incident asthma - A meta-analysis of prospective epidemiologic studies [J].
Beuther, David A. ;
Sutherland, E. Rand .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2007, 175 (07) :661-666
[6]   Effect of Body Mass Index on respiratory parameters: A cross-sectional analytical Study [J].
Bhatti, Urooj ;
Laghari, Zulfiqar Ali ;
Syed, Binafsha Manzoor .
PAKISTAN JOURNAL OF MEDICAL SCIENCES, 2019, 35 (06) :1724-1729
[7]   Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator [J].
Bowden, Jack ;
Smith, George Davey ;
Haycock, Philip C. ;
Burgess, Stephen .
GENETIC EPIDEMIOLOGY, 2016, 40 (04) :304-314
[8]   Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression [J].
Bowden, Jack ;
Smith, George Davey ;
Burgess, Stephen .
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2015, 44 (02) :512-525
[9]   A robust and efficient method for Mendelian randomization with hundreds of genetic variants [J].
Burgess, Stephen ;
Foley, Christopher N. ;
Allara, Elias ;
Staley, James R. ;
Howson, Joanna M. M. .
NATURE COMMUNICATIONS, 2020, 11 (01)
[10]   Bias due to participant overlap in two-sample Mendelian randomization [J].
Burgess, Stephen ;
Davies, Neil M. ;
Thompson, Simon G. .
GENETIC EPIDEMIOLOGY, 2016, 40 (07) :597-608