Challenges and Breakthroughs in Z-Enantioselective Olefin Metathesis

被引：5

作者：

Morvan, Jennifer ^{[1
]}

Del Vecchio, Antonio ^{[1
]}

Talcik, Jakub ^{[1
]}

Bouetard, Dylan ^{[1
]}

Mauduit, Marc ^{[1
]}

机构：

[1] Univ Rennes, Ecole Natl Super Chim Rennes, CNRS, ISCR UMR 6226, F-35000 Rennes, France

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2023年

关键词：

catalysts synthesis; Z-enantioselectivity; molybdenum-complexes; olefin metathesis; ruthenium-complexes; RING-OPENING/CROSS-METATHESIS; SELECTIVE CROSS-METATHESIS; CYCLIC (ALKYL)(AMINO)CARBENES CAACS; N-HETEROCYCLIC CARBENES; ALKYL AMINO CARBENES; Z-UNSATURATED ESTERS; CLOSING METATHESIS; RUTHENIUM CATALYSTS; STEREOSELECTIVE-SYNTHESIS; ENOL ETHERS;

D O I：

10.1002/ejoc.202300671

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Asymmetric Olefin Metathesis (AOM) represents a highly versatile synthetic tool to lead to relevant chiral building blocks with excellent enantiopurity. As the Z-alkene moiety is ubiquitous in a wide range of natural products, the development of catalysts which are able to control both the Z-selectivity and the enantioselectivity of metathesis transformations is in high demands. This review aims to provide a comprehensive overview covering all the breakthroughs accomplished in the field of challenging Z-enantioselective olefin metathesis, which is of interest in the total synthesis of complex molecules.

引用

页数：17

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