Global democratisation of proton radiotherapy

被引：50

作者：

Yan, Susu ^{[1
,2
,6
,7
]}

Ngoma, Twalib A. ^{[3
]}

Ngwa, Wilfred ^{[4
,5
]}

Bortfeld, Thomas R. ^{[1
,2
]}

机构：

[1] Massachusetts Gen Hosp, Dept Radiat Oncol, Div Radiat Biophys, Boston, MA USA

[2] Harvard Med Sch, Boston, MA USA

[3] Muhimbili Univ Hlth & Allied Sci, Dept Clin Oncol, Dar Es Salaam, Tanzania

[4] Johns Hopkins Univ, Johns Hopkins Sch Med, Dept Radiat Oncol & Mol Radiat Sci, Baltimore, MD USA

[5] ICT Univ, Dept Informat & Sci, Yaounde, Cameroon

[6] Massachusetts Gen Hosp, Dept Radiat Oncol, Div Radiat Biophys, Boston, MA 02114 USA

[7] Harvard Med Sch, Boston, MA 02114 USA

来源：

LANCET ONCOLOGY | 2023年 / 24卷 / 06期

基金：

美国国家卫生研究院;

关键词：

MODEL-BASED SELECTION; CANCER-PATIENTS; THERAPY; FEASIBILITY; EXPERIENCES; GENERATION; DELIVERY; POSITION; SYSTEM;

D O I：

10.1016/S1470-2045(23)00184-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Proton radiotherapy is an advanced treatment option compared with conventional x-ray treatment, delivering much lower doses of radiation to healthy tissues surrounding the tumour. However, proton therapy is currently not widely available. In this Review, we summarise the evolution of proton therapy to date, together with the benefits to patients and society. These developments have led to an exponential growth in the number of hospitals using proton radiotherapy worldwide. However, the gap between the number of patients who should be treated with proton radiotherapy and those who have access to it remains large. We summarise the ongoing research and development that is contributing to closing this gap, including the improvement of treatment efficiency and efficacy, and advances in fixed-beam treatments that do not require an enormously large, heavy, and costly gantry. The ultimate goal of decreasing the size of proton therapy machines to fit into standard treatment rooms appears to be within reach, and we discuss future research and development opportunities to achieve this goal.

引用

页码：E245 / E254

页数：10

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