A quarter of a century fundamental and translational research in perioperative hypersensitivity and anaphylaxis at the Antwerp university hospital, a Belgian Centre of Excellence of the World Allergy Organization

被引：1

作者：

Ebo, Didier G. ^{[1
,2
,3
,7
]}

Vlaeminck, Nils ^{[1
,2
,4
]}

van der Poorten, Marie-Line M. ^{[1
,2
,5
]}

Elst, Jessy ^{[1
,2
]}

Toscano, Alessandro ^{[1
,2
,6
]}

Van Gasse, Athina L. ^{[1
,2
,5
]}

Hagendorens, Margo M. ^{[1
,2
,5
]}

Aerts, Sophie ^{[4
]}

Adriaensens, Ine ^{[4
]}

Saldien, Vera ^{[4
]}

Sabato, Vito ^{[1
,2
,3
]}

机构：

[1] Univ Antwerp, Antwerp Univ Hosp, Fac Med & Hlth Sci, Dept Immunol Allergol Rheumatol, Antwerp, Belgium

[2] Univ Antwerp, Infla MedCtr Excellence, Antwerp, Belgium

[3] AZ Jan Palfijn Gent, Dept Immunol & Allergol, Ghent, Belgium

[4] Univ ofAntwerp, Antwerp Univ Hosp, Fac Med & Hlth Sci, Dept Anaesthesiol, Antwerp, Belgium

[5] Univ Antwerp, Antwerp Univ Hosp, Fac Med & Hlth Sci, Dept Paediat, Antwerp, Belgium

[6] Univ Milan, Postgrad Sch Allergol & Clin Immunol, Milan, Italy

[7] Univ Antwerp, Lab Immunol, CDE T5 95 Univ Pl 1, B-2610 Antwerp, Belgium

来源：

WORLD ALLERGY ORGANIZATION JOURNAL | 2023年 / 16卷 / 03期

关键词：

Perioperative hypersensitivity; Basophils; Mast cell; MRGPRX2; sIgE; MAST-CELL ACTIVATION; NEUROMUSCULAR BLOCKING-AGENTS; IMMUNOGLOBULIN-E ANTIBODIES; BASOPHIL ACTIVATION; IGE ANTIBODIES; CEFAZOLIN HYPERSENSITIVITY; DRUG HYPERSENSITIVITY; PENICILLIN ALLERGY; DIAGNOSIS; TRYPTASE;

D O I：

10.1016/j.waojou.2023.100759

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Perioperative hypersensitivity constitutes an important health issue, with potential dramatic con-sequences of diagnostic mistakes. However, safe and correct diagnosis is not always straightfor-ward, mainly because of the application of incorrect nomenclature, absence of easy accessible in-vitro/ex-vivo tests and uncertainties associated with the non-irritating skin test concentrations. In this editorial we summarize the time line, seminal findings, and major realizations of 25 years of research on the mechanisms, diagnosis, and management of perioperative hypersensitivity.

引用

页数：11

共 83 条

[1] Revisiting the role of MRGPRX2 on hypersensitivity reactions to neuromuscular blocking drugs [J].