Genetic mechanisms underlying arrhythmogenic mitral valve prolapse: Current and future perspectives

被引：5

作者：

Levy, Sydney ^{[1
,2
]}

Dabbagh, Ghaith Sharaf ^{[3
,4
]}

Giudicessi, John R. ^{[5
,6
,7
]}

Haqqani, Haris ^{[8
]}

Khanji, Mohammed Y. ^{[1
,10
,11
]}

Obeng-Gyimah, Edmond ^{[12
]}

Betts, Megan N. ^{[3
]}

Ricci, Fabrizio ^{[13
,14
,15
]}

Asatryan, Babken ^{[16
]}

Bouatia-Naji, Nabila ^{[17
]}

Nazarian, Saman ^{[18
]}

Chahal, C. Anwar A. ^{[3
,9
,19
,20
]}

机构：

[1] Byram Hills High Sch, Armonk, NY USA

[2] Harvard Univ, Cambridge, MA USA

[3] WellSpan Hlth, Ctr Inherited Cardiovasc Dis, Lancaster, PA USA

[4] Univ Michigan, Div Cardiovasc Med, Ann Arbor, MI 48109 USA

[5] Mayo Clin, Div Heart Rhythm Serv, Rochester, MN USA

[6] Mayo Clin, Div Circulatory Failure, Dept Cardiovasc Med, Dept Mol Pharmacol, Rochester, MN USA

[7] Mayo Clin, Dept Expt Therapeut, Rochester, MN USA

[8] Prince Charles Hosp, Chermside, Australia

[9] Barts Hlth NHS Trust, Barts Heart Ctr, London, West Smithfield, England

[10] Queen Mary Univ London, William Harvey Res Inst, NIHR Barts Biomed Res Ctr, London, England

[11] Barts Hlth NHS Trust, Newham Univ Hosp, London, England

[12] WellSpan Hlth, VT & Complex Ablat Program, Clin Cardiac Electrophysiol, York, N Yorkshire, England

[13] G dAnnunzio Univ Chieti Pescara, Dept Neurosci Imaging & Clin Sci, Chieti, Italy

[14] Lund Univ, Dept Clin Sci, Malmo, Sweden

[15] Fdn Villaserena Ric, Citta S Angelo, Italy

[16] Johns Hopkins Univ, Sch Med, Dept Med, Div Cardiol, Baltimore, MD 21205 USA

[17] Univ Paris Cite, INSERM, PARCC, Paris, France

[18] Univ Penn, Perelman Sch Med, Div Cardiol, Philadelphia, PA 19104 USA

[19] Hosp Univ Penn, Cardiovasc Div, Cardiac Electrophysiol, 3400 Spruce St, Philadelphia, PA 19104 USA

[20] Mayo Clin, Dept Cardiovasc Med, Rochester, MN USA

来源：

HEART RHYTHM O2 | 2023年 / 4卷 / 09期

关键词：

Mitral valve prolapse; Cardiac arrhythmia; Sudden cardiac death; Genetics; Mitral annular dysjunction; VALVULAR DYSTROPHY; POSTERIOR LEAFLET; FILAMIN-A; MUTATIONS; ASSOCIATION; LOCUS; REGURGITATION;

D O I：

10.1016/j.hroo.2023.08.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mitral valve prolapse (MVP) is a heart valve disease that is often familial, affecting 2%-3% of the general population. MVP with or without mitral regurgitation can be associated with an increased risk of ventricular arrhythmias and sudden cardiac death (SCD). Research on familial MVP has specifically focused on genetic factors, which may explain the heritable component of the disease estimated to be present in 20%-35%. Furthermore, the structural and electrophysiological substrates underlying SCD/ventricular arrhythmia risk in MVP have been studied postmortem and in the electrophysiology laboratory, respectively. Understanding how familial MVP and rhythm disorders are related may help patients with MVP by individualizing risk and working to develop effective management strategies. This contemporary, state-of-the-art, expert review focuses on genetic factors and familial components that underlie MVP and arrhythmia and encapsulates clinical, genetic, and electrophysiological issues that should be the objectives of future research.

引用

页码：581 / 591

页数：11

共 51 条

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