HOTAIR as a diagnostic and prognostic biomarker of gastrointestinal cancers: an updated meta-analysis and bioinformatics analysis based on TCGA data

被引:6
作者
Yang, Jinyou [1 ]
Xu, Shuyu [2 ]
Wang, Shaozhuo [2 ]
Zou, Xuyan [2 ]
Duan, Mingxiu [2 ]
Zhang, Qiaoling [3 ]
Wang, Chao [2 ]
机构
[1] Jiangsu Coll Nursing, Dept Hlth & Rehabil, Huaian 223005, Jiangsu, Peoples R China
[2] Nanjing Med Univ, Sch Publ Hlth, Dept Occupat Med & Environm Hlth, Key Lab Modern Toxicol Minist Educ, 101 Longmian Ave, Nanjing 211166, Peoples R China
[3] Jiangsu Coll Nursing, Dept Nursing & Midwifery, Huaian 223005, Jiangsu, Peoples R China
基金
中国国家自然科学基金;
关键词
LONG NONCODING RNA; EPITHELIAL-MESENCHYMAL TRANSITION; SQUAMOUS-CELL CARCINOMA; LNCRNA HOTAIR; POOR-PROGNOSIS; CLINICAL-SIGNIFICANCE; SIGNALING PATHWAY; GENETIC-VARIANTS; TUMOR INVASION; EXPRESSION;
D O I
10.1042/BSR20222174
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Gastrointestinal cancers are the most common type of cancer affecting humans. High expression of HOX transcript antisense intergenic RNA (HOTAIR), a long noncoding RNA (lncRNA), in various types of different tumors may be associated with poor prognosis. In the present study, we performed a meta-analysis of the relationship between HOTAIR expression and gastrointestinal cancers. Five databases were comprehensively searched for all literature until January 2023. Moreover, the target genes of HOTAIR were predicted by coexpression analysis based on The Cancer Genome Atlas (TCGA) gene expression matrix for six gastrointestinal cancer types. Finally, the mechanism through which HOTAIR affects tumors of the digestive system was systematically reviewed. Our results showed that the high HOTAIR expression group had worse outcomes with a pooled hazard ratio (HR) of 1.56 (95% confidence interval [CI] = 1.38-1.75, P<0.001). Furthermore, HOTAIR was identified as an unfavorable prognostic factor for overall survival (OS) in the esophageal carcinoma (ESCA) and gastric cancer (GC), as the HR were 1.94 and 1.58, respectively. The high correlation between the expression of homeobox C (HOXC) family genes and HOTAIR, with correlation coefficients of 0.863 (HOXC11), 0.664 (HOXC10), 0.645 (HOXC8), and 0.581 (HOXC12). The 'cell cycle' pathway and pathways relating to infections, namely 'herpes simplex virus 1 infection' and 'complement and coagulation cascades' were significantly enriched in Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. Also, we perform a systematic review to summarize the related oncogenic mechanism of HOTAIR. In conclusion, the HOTAIR has been identified as a potential prognostic factor in patients with gastrointestinal cancers.
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页数:20
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