Long-Term Protective Effects and Mechanisms of Gastric Bypass Surgery on the Kidneys in Hypertensive Obese Rat

被引：2

作者：

Zhang, Yuan ^{[1
,2
]}

Kong, Xiangxin ^{[1
,2
]}

Song, Ke ^{[1
,2
]}

He, Ming ^{[1
]}

Xian, Yin ^{[3
]}

Xie, Xing ^{[1
]}

Cheng, Junming ^{[5
]}

Bai, Rubing ^{[1
]}

Ren, Yixing ^{[1
,4
]}

机构：

[1] North Sichuan Med Coll, Affiliated Hosp, Dept Gastroenterol, South Maoyuan Rd, Nanchong 637000, Sichuan, Peoples R China

[2] North Sichuan Med Coll, Inst Hepatobiliary Pancreat & Gastroenterol, Nanchong 637000, Peoples R China

[3] Nanchong Psychosomat Hosp, Nanchong 637000, Peoples R China

[4] Xinhua Hosp, Gen Surg, Chengdu 610000, Peoples R China

[5] Peoples Hosp Dazhu Cty, Dazhou 635100, Sichuan, Peoples R China

来源：

OBESITY SURGERY | 2024年 / 34卷 / 04期

基金：

中国国家自然科学基金;

关键词：

RYGB; Obesity; Hypertension; Kidney; Bariatric surgery; Gastric bypass surgery; BLOOD-PRESSURE; INFLAMMATION; ACTIVATION;

D O I：

10.1007/s11695-024-07108-5

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

ObjectiveInvestigate the long-term protective effects of gastric bypass surgery on the kidneys of hypertensive obese rats to better understand the role of gastric bypass surgery in preventing renal injury in humans with hypertension and obesity.MethodsCompare 6-week-old spontaneously hypertensive rats, including 30 Roux-en-Y gastric bypass (RYGB) and 30 sham operations. Body weight and blood pressure were monitored before and up to 12 months after the operation. Blood lipids, blood creatinine, and blood urea nitrogen were measured. Kidney pathology was assessed using HE staining, while renal fibrosis was observed via Masson staining. Inflammatory indicators were examined by ELISA. The expression of the NLRP3 gene in the kidney was measured using immunofluorescence and western blot, and the changes in key pathways including ASC/IL-1 beta protein were verified.ResultsRYGB reduced the body weight of hypertensive obese rats and had a protective effect on blood pressure. Additionally, the bypass effectively mitigated renal inflammation and fibrosis. Moreover, RYGB modulated the expression of NLRP3 and prevented kidney damage via the ASC/IL-1 pathway.ConclusionThis study validates that RYGB effectively attains sustained blood pressure control in hypertensive obese rats and has a potential kidney-protective mechanism via the NLRP3-ASC/IL-1 beta pathway.

引用

页码：1257 / 1266

页数：10

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