Time-frequency analysis of laser speckle contrast for transcranial assessment of cerebral blood flow

被引：10

作者：

Golubova, Nadezhda ^{[1
]}

Potapova, Elena ^{[1
]}

Seryogina, Evgeniya ^{[1
]}

Dremin, Viktor ^{[1
]}

机构：

[1] Orel State Univ, Res & Dev Ctr Biomed Photon, 95 Komsomolskaya St, Oryol 302026, Russia

来源：

BIOMEDICAL SIGNAL PROCESSING AND CONTROL | 2023年 / 85卷

基金：

俄罗斯科学基金会;

关键词：

Laser speckle contrast imaging; Cerebral blood flow dynamics; Wavelet transform; DOPPLER FLOWMETRY; MICROCIRCULATION; DYNAMICS; BRAIN;

D O I：

10.1016/j.bspc.2023.104969

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Improving noninvasive approaches to monitoring blood microcirculation is an urgent topic in modern biomedical engineering. One of the actively developing methods is laser speckle contrast imaging (LSCI), which allows not only the visualization of microvessels but also the quantitative measurements of microcirculatory blood flow. This work shows the application of LSCI for mapping the cerebral vessels of a laboratory animal, and also presents the time-frequency processing of the registered signal. Thus, we expand the capabilities of the existing LSCI approach and demonstrate spatial mapping of blood flow rhythms. The proposed technology makes it possible not only to measure the relative cerebral blood flow but also to expand diagnostic capabilities for a detailed analysis of the physiological mechanisms of changes in blood flow.

引用

页数：7

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