Anti-inflammatory cembrane-based diterpenoids isolated from the octocoral Sinularia querciformis

被引：1

作者：

Kung, Te-An ^{[1
]}

Chen, Lo-Yun ^{[2
]}

Li, Chia-Ying ^{[3
]}

Peng, Bo-Rong ^{[2
]}

Hwang, Tsong-Long ^{[4
,5
,6
,7
]}

Sung, Ping-Jyun ^{[8
,9
,10
,11
,12
]}

Lai, Kuei-Hung ^{[2
,13
,14
,15
]}

Chung, Hsu -Ming ^{[3
]}

机构：

[1] Natl Pingtung Univ Sci & Technol, Inst Food Safety Management, Pingtung 91201, Taiwan

[2] Taipei Med Univ, Grad Inst Pharmacognosy, Coll Pharm, Taipei 11031, Taiwan

[3] Natl Pingtung Univ, Dept Appl Chem, Pingtung 900393, Taiwan

[4] Chang Gung Univ, Grad Inst Nat Prod, Coll Med, Taoyuan 333323, Taiwan

[5] Chang Gung Univ Sci & Technol, Grad Inst Hlth Ind Technol, Coll Human Ecol, Res Ctr Chinese Herbal Med, Taoyuan 333324, Taiwan

[6] Ming Chi Univ Technol, Dept Chem Engn, New Taipei City 243303, Taiwan

[7] Chang Gung Mem Hosp, Dept Anesthesiol, Taoyuan 333423, Taiwan

[8] Natl Museum Marine Biol & Aquarium, Pingtung 944401, Taiwan

[9] Natl Sun Yat sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804201, Taiwan

[10] China Med Univ Hosp, Chinese Med Res & Dev Ctr, Taichung 404394, Taiwan

[11] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807378, Taiwan

[12] Fu Jen Catholic Univ, Ph D Program Pharmaceut Biotechnol, New Taipei City 242062, Taiwan

[13] Taipei Med Univ, Coll Pharm, Ph D Program Clin Drug Dev Herbal Med, Taipei 11031, Taiwan

[14] Taipei Med Univ Hosp, Tradit Herbal Med Res Ctr, Taipei 11031, Taiwan

[15] Taipei Med Univ, Coll Pharm, Clin Drug Dev Herbal Med, Taipei 11031, Taiwan

来源：

PHYTOCHEMISTRY LETTERS | 2023年 / 55卷

关键词：

Cembranoid; Sinularia querciformis; Anti-inflammation; Elastase release; MARINE NATURAL-PRODUCTS; OXYGENATED CEMBRANOIDS;

D O I：

10.1016/j.phytol.2023.03.004

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The exploration of Sinularia querciformis cembranoids afforded two new compounds, querciformolide G (1) and H (2), along with three known ones, sinulaparvalide (3), sinulariolone acetate (4), and 3,4:8,11-bisepoxy-7-hydrox-ycembra-15(17)-en-1,12-olide (5). The structural elucidation of these compounds was achieved by extensive spectroscopic (IR, ESIMS, 1D and 2D NMR data) analysis and by comparison with those previously reported in the literature. Compounds 1-5 were evaluated for their anti-inflammatory activity. Among all, compound 1 displayed significant inhibitory effects on the elastase release in activated human neutrophils.

引用

页码：12 / 16

页数：5

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